Risk Role of Genetically Predicted Serum Iron Status on Thyroid Cancer.
Previous research has not clearly illustrated the impact of serum iron status on thyroid cancer. Bi-directional and multivariable Mendelian randomization (MVMR) analyses were conducted to determine the causative effects of serum iron status on thyroid cancer. Genetic markers for serum iron status, i...
| Publicado en: | Nutrition & Cancer Vol. 77; no. 7/8; pp. 888 - 901 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=186911568&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 186911568 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2025 vid: 77 iid: 7/8 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 186911568 185844925 186911568 186911568 10.1080/01635581.2025.2515659 186911568 ppf: 888 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Risk Role of Genetically Predicted Serum Iron Status on Thyroid Cancer. aug: au: Tian, Xiao Liu, Ting Ren, Xiubao affil: Department of Immunology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China sug: subj: Thyroid Neoplasms Familial and Genetic Thyroid Neoplasms Risk Factors Genetic Risk Score Risk Assessment Iron Blood Biological Markers Blood Genetic Markers Causal Attribution Human Funding Source Prediction Models Thyroid Neoplasms Prevention and Control Thyroid Neoplasms Prognosis Thyroid Neoplasms Therapy Mendelian Randomization Multivariate Analysis Ferritin Blood Transferrin Blood Sensitivity and Specificity Diagnosis, Differential ab: Previous research has not clearly illustrated the impact of serum iron status on thyroid cancer. Bi-directional and multivariable Mendelian randomization (MVMR) analyses were conducted to determine the causative effects of serum iron status on thyroid cancer. Genetic markers for serum iron status, including serum iron, ferritin, transferrin saturation (TSTA), and transferrin, were acquired from the Genetics of Iron Status. The primary analytical method employed was inverse variance weighting, supplemented by other sensitivity approaches to validate the consistency of the results. Genetically predicted serum iron, ferritin, and TSTA were found to increase the risk of thyroid cancer. However, there was no causal link between transferrin levels and the risk of thyroid cancer. The causal link remained strong in the reverse MR and MVMR. Furthermore, serum iron status had no causal effect on benign neoplasms of the thyroid gland based on the two-sample MR analysis. Our MR study provides novel evidence that serum iron, ferritin, and TSTA are associated with thyroid cancer, but not with benign neoplasms of the thyroid gland. These markers could be useful for differential diagnosis. Strategies to lower serum iron levels may reduce the burden of thyroid cancer. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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