Effect of Creatine Supplementation on Body Composition in Cancer Patients: A Systematic Review.

Creatine is a naturally occurring compound stored in muscles, obtainable through diet and supplementation, known to enhance strength, exercise capacity, and recovery. Recent research suggests it may aid in treating some chronic diseases. This review analyzed the effects of creatine supplementation (...

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Publicado en:Nutrition & Cancer Vol. 77; no. 7/8; pp. 760 - 772
Autores principales: del Arco, Asier, Aguirre-Elordui, Saioa, Olasagasti-Ibargoien, Jurgi, Castañeda-Babarro, Arkaitz
Formato: research systematic review tables/charts Journal Article
Publicado: Taylor & Francis Ltd 2025
Acceso en línea:Ver este registro en EBSCOhost
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        10.1080/01635581.2025.2519965
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        atl: Effect of Creatine Supplementation on Body Composition in Cancer Patients: A Systematic Review.
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          del Arco, Asier
          Aguirre-Elordui, Saioa
          Olasagasti-Ibargoien, Jurgi
          Castañeda-Babarro, Arkaitz
        affil: Health, Physical Activity and Sports Science Laboratory, Department of Physical Activity and Sports, University of Deusto, Bilbao, Spain
      sug:
        subj:
          Neoplasms Diet Therapy
          Neoplasms Drug Therapy
          Creatine Therapeutic Use
          Creatine Adverse Effects
          Dietary Supplements Therapeutic Use
          Dietary Supplements Adverse Effects
          Body Composition Drug Effects
          Cancer Patients Psychosocial Factors
          Cancer Survivors Psychosocial Factors
          Human
          Male
          Female
          Middle Age
          Systematic Review
          PubMed
          Medline
          Cochrane Library
          Muscle, Skeletal Drug Effects
          Adipose Tissue Drug Effects
          Muscle Strength Drug Effects
          Nutritional Support
          Physical Fitness
          Funding Source
          Middle Aged: 45-64 years
          Male
          Female
      ab: Creatine is a naturally occurring compound stored in muscles, obtainable through diet and supplementation, known to enhance strength, exercise capacity, and recovery. Recent research suggests it may aid in treating some chronic diseases. This review analyzed the effects of creatine supplementation (CrS) on body composition in cancer patients or survivors. Following PRISMA guidelines, five databases were searched for studies up to September 12, reviewing seven articles with 463 participants (316 men, 147 women; average age 62.95 years). Five studies assessed CrS effects on body weight: three found no changes, while two reported increases. For lean body mass, three trials noted increases in both creatine and placebo groups, but differences were not significant. Fat mass results varied, showing reductions, no changes, or mitigated increases during hormone therapy. Although CrS showed potential improvements, evidence of significant effects on body composition in cancer patients remains limited. CrS appears safe and might be more beneficial with less aggressive treatments or in non-metastatic cases. Further research is needed to clarify its role in this context.
      pubtype: Academic Journal
      doctype:
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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