Cancer and Accelerated Aging Research at the National Institutes of Health, 2013–2023: A Grant Portfolio Analysis.
Background: The purpose of this study was to describe the characteristics of the NIH‐funded grant portfolio focused on cancer and accelerated aging. Methods: Research project grants focused on cancer survivors and aging trajectories that were newly funded during fiscal years 2013 through 2023 were i...
| Publicado en: | Journal of the American Geriatrics Society Vol. 73; no. 7; pp. 2029 - 2037 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
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Wiley-Blackwell
Jul2025
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=186990641&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 186990641 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00028614 20Q jtl: Journal of the American Geriatrics Society issn: 00028614 maglogo: Y pubinfo: dt: Jul2025 vid: 73 iid: 7 pid: 480 pub: Wiley-Blackwell artinfo: ui: 186990641 10.1111/jgs.19414 ppf: 2029 ppct: 8 formats: tig: atl: Cancer and Accelerated Aging Research at the National Institutes of Health, 2013–2023: A Grant Portfolio Analysis. aug: au: Gallicchio, Lisa Brick, Rachelle Tesauro, Gina Page, Lindsey Green, Paige Guida, Jennifer L. affil: Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville Maryland,, USA Healthcare Delivery Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville Maryland,, USA Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville Maryland,, USA Office of Cancer Survivorship, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville Maryland,, USA su: National Institutes of Health (U.S.) Medical research Aging Rural population Cognition Endowments Scientific observation Descriptive statistics Functional status Cancer patients Tumors Algorithms Biomarkers sug: subj: Medical research Aging Rural population Cognition National Institutes of Health (U.S.) Grantmaking Foundations Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology) Endowments Scientific observation Descriptive statistics Functional status Cancer patients Tumors Algorithms Biomarkers keyword: aging trajectories biomarkers cancer survivors NIH grant funding aging trajectories biomarkers cancer survivors NIH grant funding ab: Background: The purpose of this study was to describe the characteristics of the NIH‐funded grant portfolio focused on cancer and accelerated aging. Methods: Research project grants focused on cancer survivors and aging trajectories that were newly funded during fiscal years 2013 through 2023 were identified by first using a text mining algorithm from the NIH Research, Condition, and Disease Categorization (RCDC) system with cancer survivorship‐relevant terms and then a list of aging‐related terms that included aging, neurocognition, and physical function. Included grants were double coded to extract study characteristics. Results: A total of 166 grants were identified, with the National Cancer Institute (NCI) and National Institute on Aging (NIA) funding 62.0% and 23.5% of the grants, respectively. The number of newly funded grants rose from nine in 2013 to 27 in 2023. Overall, the majority were observational studies (65.1%); 45% included study samples of multiple cancer types. The most commonly examined outcomes were cognitive (54.4%) or physical (37.5%) functioning; 30% of grants incorporated an aging‐related biomarker. Few grants focused on racial and ethnic minority (3.0%) or rural cancer survivors (2.4%). Conclusions: This portfolio analysis showed an increase in the number of NIH‐funded grants focused on cancer survivors and accelerated aging, but notable gaps are evident. Given the rapidly growing survivor population, many of whom will experience accelerated aging trajectories, there is a critical need to better understand accelerated aging phenotypes and mechanisms, so that those at the highest risk for adverse aging‐related effects can be identified and interventions developed. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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