Attention‐Deficit Hyperactivity Disorder and Childhood Allergy: Evidence From Mendelian Randomization.
Background: The association between attention‐deficit hyperactivity disorder (ADHD) and allergic diseases in children has been reported in observational studies, yet whether the relationship reflects causality remains unclear. Methods: To address this, we performed a two‐sample bidirectional Mendeli...
| Publicado en: | Child: Care, Health & Development Vol. 51; no. 4; pp. 1 - 10 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187022031&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187022031 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03051862 6NX jtl: Child: Care, Health & Development issn: 03051862 maglogo: Y pubinfo: dt: Jul2025 vid: 51 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 187022031 187022031 187022031 10.1111/cch.70135 187022031 ppf: 1 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Attention‐Deficit Hyperactivity Disorder and Childhood Allergy: Evidence From Mendelian Randomization. aug: au: Liu, Maolin Zeng, Zhongyao Song, Yuanzhi Liu, Yan Sun, Miao Wei, Guanghui Wu, Shengde Kou, Lihua affil: Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China sug: subj: Attention Deficit Hyperactivity Disorder In Infancy and Childhood Hypersensitivity In Infancy and Childhood Funding Source Human Child Mendelian Randomization Descriptive Statistics Odds Ratio Confidence Intervals Mediation Analysis Gut Microbiota Metabolites Child: 6-12 years ab: Background: The association between attention‐deficit hyperactivity disorder (ADHD) and allergic diseases in children has been reported in observational studies, yet whether the relationship reflects causality remains unclear. Methods: To address this, we performed a two‐sample bidirectional Mendelian randomization (MR) analysis using genetic instrumental variables associated with ADHD (N = 38 691) and childhood allergy (N = 5337) from the largest available genome‐wide association studies. Inverse‐variance weighted was used as the primary estimate, whereas Cochran's Q test and MR‐Egger regression were used to detect heterogeneity and pleiotropy. Results: The main MR estimates indicated that ADHD significantly associated with the risk of allergic diseases in children (odds ratio = 1.14, 95% confidence interval: 1.02–1.27, p = 0.017). The mediation analysis via two‐step MR showed no evidence for mediating roles of gut microbiota and metabolites in the effect of ADHD on childhood allergy. Conclusions: These findings may inform neuroimmune interaction and interventions for allergic diseases in children with ADHD. SUMMARY: ADHD is significantly associated with an increased risk of childhood allergic diseases.This study is the first to use Mendelian randomization to explore the potential causal relationship between ADHD and childhood allergy.No mediating effect of gut microbiota or serum metabolites was found in the causal pathway from ADHD to allergy.The findings support the hypothesis of a direct neuroimmune interaction between the brain and immune system.Early screening for allergic conditions in children with ADHD may improve clinical management and preventive strategies. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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