Efficacy of a device for training metered dose inhaler breathing proficiency: a crossover, double-blind, pilot trial in healthy volunteers.
Background: The accurate administration of inhalation medications, including metered dose inhalers (MDI), is crucial for achieving desired treatment outcomes in patients with chronic airway diseases. A simple, inexpensive, and validated device for measuring respiratory force, the NU_;spiroBreathe (N...
| Publicado en: | Pharmacy Practice (1886-3655) Vol. 23; no. 2; pp. 1 - 8 |
|---|---|
| Autores principales: | , , , |
| Formato: | pictorial research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Centro de Investigaciones y Publicaciones Farmaceuticas S.L.
Apr-Jun2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187053344&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187053344 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1885642X 3EAU jtl: Pharmacy Practice (1886-3655) issn: 1885642X maglogo: N pubinfo: dt: Apr-Jun2025 vid: 23 iid: 2 pid: 36266 pub: Centro de Investigaciones y Publicaciones Farmaceuticas S.L. artinfo: ui: 187053344 187053344 187053344 10.18549/PharmPract.2025.2.3151 187053344 ppf: 1 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Efficacy of a device for training metered dose inhaler breathing proficiency: a crossover, double-blind, pilot trial in healthy volunteers. aug: au: Poowaruttanawiwit, Prayuth Wongseree, Suphaksorn Intharali, Surada Yotsombut, Kitiyot affil: PharmD, Ph.D, The Medical and Pharmacy Innovation Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok. Thailand sug: subj: Nebulizers and Vaporizers Administration, Inhalation Education Patient Education Outcomes of Education Evaluation Human Crossover Design Double-Blind Studies Pilot Studies Randomized Controlled Trials Random Assignment Multimethod Studies Patient Safety Male Female Descriptive Statistics Male Female ab: Background: The accurate administration of inhalation medications, including metered dose inhalers (MDI), is crucial for achieving desired treatment outcomes in patients with chronic airway diseases. A simple, inexpensive, and validated device for measuring respiratory force, the NU_;spiroBreathe (NUB), has been invented. Although preliminary use of NUB indicated its potential as a training tool for improving breathing proficiency among MDI users, its efficacy in this application has not yet been studied. Objective: This study aimed to examine the efficacy of NUB in training MDI breathing proficiency among healthy volunteers. Methods: A mixed-method pilot study was conducted, combining a crossover, double-blinded, placebo-controlled trial with an AI-assisted qualitative study. Healthy participants were instructed to perform oral inhalation using NUB, a placebo MDI (pMDI), and a NUBassisted MDI (NUB-MDI) in a crossover manner. MDI breathing proficiency was assessed by measuring inhalation time (Ti) and inhalation force (Fi). Cardiopulmonary safety was evaluated using blood pressure (BP), heart rate (HR), and arterial oxygen saturation (SpO2). Participants' opinions on NUB and other interventions were collected via a self-administered questionnaire. Results: A total of 30 participants completed the trial. They were healthy adults with an average age of 22.05 years, predominantly females. None of them had experience with any oral inhalation medications. Compared to the pMDI, the mean Ti for both NUB and NUB-MDI were statistically higher with the mean differences of 6.73 seconds [95% confidence interval (CI) 3.22 to 10.245, p < .001] and 6.10 seconds [95%CI 3.00 to 9.20, p < .001], respectively. While no significant difference in Ti was found between NUB and NUB-MDI, the mean Fi for NUB-MDI was marginally higher than that of the NUB group (mean difference of 1.48 cmH2O, [95%CI 0.36 to 2.60, p = .011]). Cardiopulmonary parameters showed no statistical changes. Content analysis of participants' opinions corroborated the quantitative findings. Conclusion: The NUB device could serve as a useful training tool for improving MDI breathing proficiency. However, further studies in real-world clinical settings were warranted (registration number: TCTR20230401004) pubtype: Academic Journal doctype: pictorial research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|