Pleasurable music activates cerebral µ-opioid receptors: a combined PET-fMRI study.
Purpose: The μ-opioid receptor (MOR) system mediates incentive motivation and the hedonic component of primary rewards such as food and sex. However, there is no direct in vivo evidence for the involvement of the MOR system in pleasure derived from aesthetic rewards such as music. Methods: We measur...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 52; no. 10; pp. 3540 - 3550 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187119037&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187119037 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Aug2025 vid: 52 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 187119037 184223064 10.1007/s00259-025-07232-z 187119037 ppf: 3540 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Pleasurable music activates cerebral µ-opioid receptors: a combined PET-fMRI study. aug: au: Putkinen, Vesa Seppälä, Kerttu Harju, Harri Hirvonen, Jussi Karlsson, Henry K. Nummenmaa, Lauri affil: https://ror.org/01761e930 Turku PET Centre, and Turku University Hospital, University of Turku, Turku, Finland sug: ab: Purpose: The μ-opioid receptor (MOR) system mediates incentive motivation and the hedonic component of primary rewards such as food and sex. However, there is no direct in vivo evidence for the involvement of the MOR system in pleasure derived from aesthetic rewards such as music. Methods: We measured MOR availability with positron emission tomography (PET) and the agonist radioligand [11C]carfentanil with high affinity for MORs during the listening of pleasurable music and neutral baseline condition. Haemodynamic responses associated with dynamic pleasure ratings during listening to music and control stimuli were measured using functional magnetic resonance imaging (fMRI). Results: The PET results revealed that pleasurable music increased [11C]carfentanil binding in several cortical and subcortical regions, including ventral striatum and orbitofrontal cortex, known to contain "hedonic hotspots". [11C]carfentanil binding in the nucleus accumbens during the music condition was associated with number of pleasurable chills, linking the subjective experience of pleasure to striatal opioid release. Individual variation in baseline MOR tone influenced pleasure-dependent haemodynamic responses during music listening in regions associated with interoceptive, sensorimotor, and reward processing. Conclusions: These findings provide the first neuroimaging evidence that pleasurable music modulates MOR system function. The results indicate that the μ-opioid system governs complex aesthetic rewards in addition to biologically essential primary rewards. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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