The diagnostic performance of [18F]Florbetazine in Alzheimer's disease: a head-to-head comparison to [11C]PiB and [18F]Florbetapir.
Purpose: This study aims to compare [18F]Florbetazine (FBZ, [18F]92) with [11C]Pittsburgh compound B (PiB) and [18F]Florbetapir (FBP) PET imaging to evaluate the diagnostic efficacy of FBZ and explore differences in topographical deposition patterns between FBZ and PiB/FBP. Methods: Seventy-eight pa...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 52; no. 10; pp. 3557 - 3567 |
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| Autores principales: | , , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187119038&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187119038 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Aug2025 vid: 52 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 187119038 184253782 10.1007/s00259-025-07233-y 187119038 ppf: 3557 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The diagnostic performance of [18F]Florbetazine in Alzheimer's disease: a head-to-head comparison to [11C]PiB and [18F]Florbetapir. aug: au: Wu, Meiqi Li, Yuying Liang, Menglin Mao, Chenhui Dong, Liling Ge, Qi Wu, Runze Ren, Chao Zhang, Haiqiong Huang, Zhenghai Xing, Haiqun Yang, Xueqian Wang, Yuan Feng, Feng Cui, Mengchao Gao, Jing Huo, Li affil: https://ror.org/02drdmm93 Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China sug: ab: Purpose: This study aims to compare [18F]Florbetazine (FBZ, [18F]92) with [11C]Pittsburgh compound B (PiB) and [18F]Florbetapir (FBP) PET imaging to evaluate the diagnostic efficacy of FBZ and explore differences in topographical deposition patterns between FBZ and PiB/FBP. Methods: Seventy-eight participants were included, with 40 in the FBZ-PiB subgroup (9 healthy controls [HCs], 9 with non-AD dementia, and 22 with AD) and 38 in the FBZ-FBP subgroup (10 HCs, 9 with non-AD dementia, 1 with mild cognitive impairment [MCI], and 18 with AD). All images were visually evaluated by two trained nuclear medicine physicians and quantitatively analyzed using global and regional standardized uptake value ratio (SUVr). Results: Visual interpretation of FBZ scans achieved a diagnostic sensitivity of 100% and a specificity of 97%, with complete concordance with PiB and FBP. Positive FBZ PET scans showed higher gray matter uptake relative to white matter, closely resembling the cortical distribution of PiB but offering greater gray-to-white matter contrast compared to both PiB (1.19(0.17) vs. 1.11(0.15), P < 0.001) and FBP (1.27(0.24) vs. 0.86(0.13), P < 0.001). The global SUVr for all three radiotracers demonstrated perfect diagnostic accuracy for AD, with a cut-off range of 0.99 to 1.38 for FBZ when using the whole cerebellum as a reference. The global SUVr of FBZ strongly correlated with PiB (slope = 0.94, r = 0.99, P < 0.001) and FBP (slope = 1.74, r = 0.95, P < 0.001). Conclusion: FBZ PET imaging exhibits comparable diagnostic efficacy to PiB and FBP, with excellent correlation for Aβ quantification. Its high cortical uptake and low white matter binding favors visual interpretation in clinical practice. Clinical trial registration: NCT06141356. Registered November 2023. https://clinicaltrials.gov/search?term=NCT06141356. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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