Beyond the left cerebral hemisphere: bilateral language lateralization in healthy aging and its clinical implications.
Background: Functional MRI (fMRI) studies conducted on young adults reveal a predominantly left-lateralized cortical language network during semantic and phonological processing (SP and PP, respectively). Both linguistic dimensions have been advanced as potential cognitive markers of pathological ag...
| Publicado en: | Frontiers in Aging Neuroscience pp. 1 - 14 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187160641&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187160641 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 2025 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 187160641 187160641 187160641 10.3389/fnagi.2025.1547162 187160641 ppf: 1 ppct: 13 formats: tig: atl: Beyond the left cerebral hemisphere: bilateral language lateralization in healthy aging and its clinical implications. aug: au: Toloza-Ramirez, David Santibañez, Rodrigo Arraño-Carrasco, Leonardo Zunino-Pesce, Romina Julio-Ramos, Teresa Copland, David A. Quezada, Camilo Mendez-Orellana, Carolina affil: Interdisciplinary Center for Neuroscience, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile sug: subj: Brain Physiopathology Healthy Aging Semantics Language Processing In Old Age Task Performance and Analysis Spanish Language Human Female Male Aged Aged, 80 and Over Chileans Magnetic Resonance Imaging Language Tests Methods Psychological Tests Speech and Language Assessment Image Processing, Computer Assisted Regression Data Analysis Software Descriptive Statistics Confidence Intervals Funding Source Aged: 65+ years Aged, 80 & over Female Male ab: Background: Functional MRI (fMRI) studies conducted on young adults reveal a predominantly left-lateralized cortical language network during semantic and phonological processing (SP and PP, respectively). Both linguistic dimensions have been advanced as potential cognitive markers of pathological aging. However, the neural mechanisms underlying SP and PP among healthy older adults remain poorly understood. Aim: This study aimed to investigate the dynamics of language lateralization among native Spanish-speaking older adults in relation to their behavioral performance in specific semantic and phonological tasks. Methodology: Twenty-eight healthy, right-handed older Chilean adults (mean age: 67.7, SD±: 7.44, range: 60–87) took part in an fMRI session during which they performed semantic and phonological tasks. They were also evaluated for overall language performance using the Spanish version of ScreeLing and verbal fluency tasks. A fixed-effect analysis was performed to explore group-level differences. Standard regression analyses were also used to assess the association between brain activation and language performance. Results: Both SP and PP elicited bilateral activation in the pars triangularis and opercularis of the inferior frontal gyrus (IFG) and the superior temporal gyrus. Activation was also observed in the left inferior parietal gyrus. Semantic fluency performance was significantly associated with activation in the right angular gyrus and the pars opercularis of the IFG. In contrast, phonological fluency was associated with bilateral activation in the IFG pars orbitalis. Conclusion: Among healthy older adults, SP and PP recruit bilateral language-related brain regions, potentially reflecting compensatory mechanisms associated with normal aging. Notably, the IFG pars orbitalis may play a distinct role in supporting phonological fluency, despite not being a region traditionally linked to PP. Further research is needed to clarify the contribution of this region to phonological performance among aging adults. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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