Age-related alterations in alpha and beta oscillations support preservation of semantic processing in healthy aging.
Semantic processing remains relatively preserved during healthy aging, but the mechanisms are poorly understood. Herein, we use dynamic functional mapping based on magnetoencephalography to examine the neural oscillations serving semantic processing across the adult lifespan (N = 154; 21–87 years)....
| Publicado en: | NPJ Aging Vol. 11; no. 1; pp. 1 - 15 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
8/6/2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187166288&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187166288 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 27316068 N5IE jtl: NPJ Aging issn: 27316068 maglogo: N pubinfo: dt: 8/6/2025 vid: 11 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 187166288 187166288 187166288 10.1038/s41514-025-00263-8 187166288 ppf: 1 ppct: 14 formats: tig: atl: Age-related alterations in alpha and beta oscillations support preservation of semantic processing in healthy aging. aug: au: Hall, Megan C. Rempe, Maggie P. Casagrande, Chloe C. Glesinger, Ryan J. Petro, Nathan M. Garrison, Grant M. John, Jason A. Dietz, Sarah M. Schantell, Mikki Bai, Hua Arif, Yasra Embury, Christine M. Bashford, Seth Okelberry, Hannah J. Petts, Aubrie J. Keifer, Elizabeth L. May-Weeks, Pamela E. Picci, Giorgia Heinrichs-Graham, Elizabeth Wilson, Tony W. affil: https://ror.org/01q9r1072 Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA sug: subj: Diagnosis, Neurologic In Adulthood Diagnosis, Neurologic In Middle Age Diagnosis, Neurologic In Old Age Healthy Aging Evaluation Brain Mapping Semantics Task Performance and Analysis Human Adult Middle Age Aged Aged, 80 and Over Male Female Descriptive Statistics Brain Radiography Mediation Analysis Cluster Analysis Verbal Behavior Neurophysiology Adaptation, Physiological Electroencephalography Analysis of Variance Reaction Time Paired T-Tests Cognition Evaluation Confidence Intervals Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Semantic processing remains relatively preserved during healthy aging, but the mechanisms are poorly understood. Herein, we use dynamic functional mapping based on magnetoencephalography to examine the neural oscillations serving semantic processing across the adult lifespan (N = 154; 21–87 years). Task-related oscillatory dynamics were imaged using a beamformer and whole-brain linear mixed-effects (LME) models were calculated with age and task condition (semantically-related or -unrelated) as factors. LMEs revealed significant age-by-condition interactions on alpha and beta activity in multiple regions, which generally reflected stronger responses with increasing age and/or in the semantically-related condition across regions (p values < 0.005, corrected). Follow-up mediation analyses of these interaction clusters indicated that left perisylvian alpha responses suppressed the effect of age on verbal fluency (p = 0.014), with larger conditional differences in this region supporting preserved fluency with increasing age. Our findings provide novel insight on age-related neurophysiological adaptations that support preservation of semantic processing. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|