Interactions between bone density and muscle mass in predicting all-cause mortality: a 10-year prospective cohort study of 1388 older men (aged 77–101 years).
Background Low bone density and low muscle mass are both independent risk factors for mortality in older men. However, it is unknown if these tissues interact to increase mortality risk. Elucidating this information is important as bone and muscle are modifiable across the life cycle. Objective To e...
| Publicado en: | Age & Ageing Vol. 54; no. 7; pp. 1 - 11 |
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| Autores principales: | , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jul2025
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=187169230&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 187169230 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jul2025 vid: 54 iid: 7 pid: 622 pub: Oxford University Press / USA artinfo: ui: 187169230 10.1093/ageing/afaf189 ppf: 1 ppct: 10 formats: tig: atl: Interactions between bone density and muscle mass in predicting all-cause mortality: a 10-year prospective cohort study of 1388 older men (aged 77–101 years). aug: au: Kirk, Ben Harrison, Stephanie L Zanker, Jesse Burghardt, Andrew J Orwoll, Eric Cawthon, Peggy M Duque, Gustavo affil: The University of Melbourne Melbourne Medical School, Department of Medicine-Western Health, Melbourne, Victoria, Australia The University of Melbourne Western Clinical School at Sunshine Hospital, Australian Institute for Musculoskeletal Science (AIMSS), Saint Albans, Victoria, Australia California Pacific Medical Center Research Institute, San Francisco, CA, USA The University of Melbourne Melbourne Medical School, Department of Medicine and Aged Care, Melbourne, Victoria, Australia Oregon Health & Science University, Division of Endocrinology, Diabetes and Clinical Nutrition, School of Medicine, Portland, OR, USA California Pacific Medical Center Research Institute, San Francisco Coordinating Center, San Francisco, CA, USA University of California San Francisco, Epidemiology and Biostatistics, San Francisco, CA, USA Research Institute of the McGill University Health Centre, Bone, Muscle & Geroscience Group, Montreal, Quebec, Canada McGill University Department of Medicine, Dr. Joseph Kaufmann Chair in Geriatric Medicine, Montreal, Quebec, Canada su: United States Men's health Old age Skeletal muscle physiology Mortality risk factors Risk assessment Photon absorptiometry Bone density Computed tomography Descriptive statistics Multivariate analysis Longitudinal method Data analysis software Confidence intervals Sarcopenia Proportional hazards models sug: subj: Men's health Old age United States Irradiation Apparatus Manufacturing Skeletal muscle physiology Mortality risk factors Risk assessment Photon absorptiometry Bone density Computed tomography Descriptive statistics Multivariate analysis Longitudinal method Data analysis software Confidence intervals Sarcopenia Proportional hazards models keyword: bone–muscle interactions mortality older people osteoporosis sarcopenia bone–muscle interactions mortality older people osteoporosis sarcopenia ab: Background Low bone density and low muscle mass are both independent risk factors for mortality in older men. However, it is unknown if these tissues interact to increase mortality risk. Elucidating this information is important as bone and muscle are modifiable across the life cycle. Objective To examine whether there is an interconnection between bone density and muscle mass on all-cause mortality in older men. Design Prospective cohort study. Setting The Osteoporotic Fractures in Men study, an multicenter longitudinal study across six US sites. Participants Exposures measured at baseline visit (2014–2016) included bone density by dual-energy X-ray absorptiometry (hip, g/cm); muscle mass by creatine dilution stable isotope (whole body, kg); bone strength by high-resolution computed tomography (tibia, newtons); and muscle volume by high-resolution computed tomography (calf, mm). Covariates measured at baseline visit (2014–2016) included demographics and lifestyle factors as well as medical conditions. Main Outcome Measure All-cause mortality by death certificates and International Classification of Diseases-Ninth Revision codes measured from 2014 to 2016 through August 2024. Data analysis was performed during December 2024. Cox hazards models were used to model the relationship between the exposures and outcomes, unadjusted and adjusted for covariates. Results A total of 1388 men with a mean age of 84.2 ± 4.1 years (77–101 years, 91.6% white) were followed for 6.58 ± 2.61 years. A total of 663 (47.8%) men died. In unadjusted analyses using continuous exposures, interaction terms were significant between bone and muscle variables for all-cause mortality (P < 0.001 to 0.039). In men with low muscle mass or low muscle volume (≤50th percentile), each SD decrease in bone density increased all-cause mortality by a respective 19% (HR = 1.19 95% CI 1.07–1.34) and 29% (HR = 1.29 95% CI 1.11–1.49) in multivariable-adjusted models. Likewise, in men with low muscle mass or low muscle volume (≤50th percentile), each SD decrease in bone strength increased all-cause mortality by a respective 19% (HR = 1.19 95% CI 1.06–1.33) and 29% (HR = 1.29 95% CI 1.12–1.48) in multivariable-adjusted models. Conclusions We found consistent evidence for a combined association of bone and muscle health on all-cause mortality. Randomised controlled trials are now needed to confirm if increasing or preserving bone and muscle mass in old age reduces mortality risk. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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