Differentiation between mucinous cystic neoplasms and simple cysts of the liver: a systematic review and meta-analysis.
Purpose: Radiologic examinations frequently identify cystic liver lesions, which encompass various entities from simple benign cysts to malignant neoplasms. This work analyses the available data to compare diagnostic features of biliary cystic neoplasms and hepatic simple cysts. Methods: A systemati...
| Published in: | Abdominal Radiology Vol. 50; no. 9; pp. 4125 - 4139 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Sep2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187189766&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187189766 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Sep2025 vid: 50 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 187189766 183747258 10.1007/s00261-025-04874-3 187189766 ppf: 4125 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Differentiation between mucinous cystic neoplasms and simple cysts of the liver: a systematic review and meta-analysis. aug: au: Manzari Tavakoli, Gita Afsharzadeh, Mahshad Mobinikhaledi, Mahya Behzad, Shima Ghorani, Hamed Salahshour, Faeze affil: https://ror.org/01c4pz451 Tehran University of Medical Sciences, Tehran, Iran sug: ab: Purpose: Radiologic examinations frequently identify cystic liver lesions, which encompass various entities from simple benign cysts to malignant neoplasms. This work analyses the available data to compare diagnostic features of biliary cystic neoplasms and hepatic simple cysts. Methods: A systematic search of PubMed, Scopus, Embase, and Web of Science up to October 2024 was conducted. The characteristics were categorized into hepatic simple cysts (HSC) and mucinous cystic neoplasms (MCN), including biliary cystadenoma (BCA) and cystadenocarcinoma (BCAC) detected by imaging modalities including ultrasound, CT scans with IV contrast, or MRI. We analyzed biliary cystic neoplasms and hepatic simple cysts across multiple studies using Review Manager Ver. 5, calculating summary measures for each feature. Results: The study analyzed 577 lesions in 577 patients and 49 studies. Hepatic simple cysts were the most common finding, with 349 identified, mainly in the right hepatic lobe, presented with abdominal pain or incidentally. Intracystic septation was found in 50.1% of HSC lesions, with thick septation in 10.52% of lesions. 228 (49.9%) patients were diagnosed with MCN, with abdominal swelling and pain as the most common presentation. Septation was the most common radiological feature of MCNs, with thick septa in 50.61%. MCNs had internal septa, solid mural nodule, upstream bile duct dilation, presence in the left hepatic lobe, septal thickening, cystic wall enhancement, calcifications, and internal debris. The presence of a cyst in the left lobe was more related to MCNs. Conclusion: Characterizing cystic liver lesions necessitates a comprehensive evaluation of the lesions' location, size, and complexity. Imaging and clinical findings are essential for a final diagnosis. Highlights: Differentiating between MCNs and HSCs based on imaging features can be challenging due to the overlapping in imaging findings and the absence of definitive serum tumor markers. Wall thickness, internal septation, mural nodule, intra-cystic debris, wall enhancement, and bile duct dilation are predictive factors for mucinous cystic neoplasms along with the left lobe location. Hepatic simple cysts are generally lesions with thin and regular walls that are often multiple and affect the right lobe of the liver. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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