Correlation analysis between impaired cortical blood flow and plasma vascular cell adhesion molecule-1 levels in patients with cerebral small vessel disease.
Objective To investigate the correlation between plasma vascular cell adhesion molecule-1 (VCAM 1) levels and cortical regional blood flow impairment in patients with cerebral small vessel disease (CSVD). Methods All 67 patients with CSVD diagnosed and treated in Fu Yang People's Hospital in Anhui f...
| Publicado en: | Chinese Journal of Contemporary Neurology & Neurosurgery Vol. 25; no. 7; pp. 637 - 644 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Chinese Journal of Contemporary Neurology & Neurosurgery
Jul2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187191399&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187191399 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16726731 FDQ6 jtl: Chinese Journal of Contemporary Neurology & Neurosurgery issn: 16726731 maglogo: N pubinfo: dt: Jul2025 vid: 25 iid: 7 pid: 80951 pub: Chinese Journal of Contemporary Neurology & Neurosurgery artinfo: ui: 187191399 187191399 187191399 10.3969/j.issn.1672-6731.2025.07.011 187191399 ppf: 637 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Correlation analysis between impaired cortical blood flow and plasma vascular cell adhesion molecule-1 levels in patients with cerebral small vessel disease. aug: au: CHEN Ju-luo LIU Lu MA Pei-qi WANG Fu-xing WANG You-meng affil: Department of Neurology, Fu Yang People's Hospital, Fuyang 236000, Anhui, China sug: subj: Cerebral Small Vessel Diseases Cell Adhesion Molecule-1 Blood Cerebrovascular Circulation Human Funding Source China Female Male Middle Age Aged Correlational Studies Descriptive Statistics Pearson's Correlation Coefficient Correlation Coefficient Magnetic Resonance Imaging Methods Brain Physiology Insular Cortex Prefrontal Cortex Enzyme-Linked Immunosorbent Assay Hypertension Endothelium Injuries Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Objective To investigate the correlation between plasma vascular cell adhesion molecule-1 (VCAM 1) levels and cortical regional blood flow impairment in patients with cerebral small vessel disease (CSVD). Methods All 67 patients with CSVD diagnosed and treated in Fu Yang People's Hospital in Anhui from October 2021 to June 2023 were selected, and 55 subjects were selected as the control group. Using 3.0T MRI with 3D arterial spin labeling (3D-ASL) perfusion imaging technology to measure the cerebral blood flow (CBF) in different cortical regions, and the levels of plasma VCAM-1 were measured by enzyme-linked immunosorbent assay (ELISA). Pearson correlation analysis and partial correlation analysis were used to investigate the correlation between plasma VCAM-1 levels and CBF values in each cortical region. Results Correlation analysis showed that plasma VCAM-1 was negatively correlated with CBF value in the left superior temporal gyrus (r = - 0.285, P = 0.021), supramarginal gyrus (r = - 0.250, P = 0.044), insula lobe (r = - 0.270, P = 0.030), medial prefrontal cortex (r = - 0.329, P = 0.008), middle temporal gyrus (r = - 0.282, P = 0.023), paracentral lobule (r = - 0.274, P = 0.027), and in the right middle temporal gyrus (r = - 0.298, P = 0.016), postcentral gyrus (r = - 0.264, P = 0.033), superior temporal gyrus (r = - 0.275, P = 0.027), supramarginal gyrus (r = - 0.293, P = 0.018), insula (r = - 0.255, P = 0.041) in CSVD group, while the CBF value in the left medial prefrontal cortex in CSVD group was significantly lower than that in control group [(33.46 ± 8.27) ml/(min·100 g) vs. (36.56 ± 8.74) ml/(min·100 g); t = - 2.009, P = 0.047]. Conclusions Plasma VCAM-1 of CSVD patients may serve as a serological marker to evaluate local blood flow damage, suggesting that hypertension causes endothelial damage and inflammatory response. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: Chinese refInfo: holdings: @attributes: islocal: N |
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