Aberrant brain structural-functional coupling and structural/functional network topology explain developmental delays in pediatric Prader-Willi syndrome.
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by dysplasia in early life. Psychoradiology studies have suggested that mental and behavioral deficits in individuals with PWS are linked to abnormalities in brain structural and functional networks. However, little is known...
| Published in: | European Child & Adolescent Psychiatry Vol. 34; no. 7; pp. 2155 - 2168 |
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| Main Authors: | , , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Jul2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187234946&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187234946 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Jul2025 vid: 34 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 187234946 181756507 187234946 187234946 10.1007/s00787-024-02631-3 187234946 ppf: 2155 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Aberrant brain structural-functional coupling and structural/functional network topology explain developmental delays in pediatric Prader-Willi syndrome. aug: au: Huang, Zhongxin Zheng, Helin Wang, Longlun Ding, Shuang Li, Rong Qing, Yong Peng, Song Zhu, Min Cai, Jinhua affil: https://ror.org/05pz4ws32 Department of Radiology, Women and Children's Hospital of Chongqing Medical University, 401147, Chongqing, China sug: subj: Prader-Willi Syndrome Brain Pathology Brain Physiopathology Functional Connectivity Evaluation Developmental Disabilities Magnetic Resonance Imaging Neuroradiography Human Funding Source Male Female Child Matched Case Control Large-Scale Brain Networks Neurodevelopment Child Development Child: 6-12 years Male Female ab: Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by dysplasia in early life. Psychoradiology studies have suggested that mental and behavioral deficits in individuals with PWS are linked to abnormalities in brain structural and functional networks. However, little is known about changes in network-based structural-functional coupling and structural/functional topological properties and their correlations with developmental scales in children with PWS. Here, we acquired diffusion tensor imaging and resting-state functional magnetic resonance imaging data from 25 children with PWS and 28 age- and sex-matched healthy controls, constructed structural and functional networks, examined intergroup differences in structural-functional coupling and structural/functional topological properties (both global and nodal), and tested their partial correlations with developmental scales. We found that children with PWS exhibited (1) decreased structural-functional coupling, (2) a higher characteristic path length and lower global efficiency in the structural network in terms of global properties, (3) alterations in classical cortical and subcortical networks in terms of nodal properties, with the structural network dominated by decreases and the functional network dominated by increases, and (4) partial correlation with developmental scales, especially for functional networks. These findings suggest that structural-functional decoupling and abundant structural/functional network topological properties may reveal the mechanism of early neurodevelopmental delays in PWS from a neuroimaging perspective and might serve as potential markers to assess early neurodevelopmental backwardness in PWS. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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