A Novel Self-Supervised Learning-Based Method for Dynamic CT Brain Perfusion Imaging.
Dynamic computed tomography (CT)-based brain perfusion imaging is a non-invasive technique that can provide quantitative measurements of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT). However, due to high radiation dose, dynamic CT scan with a low tube voltage a...
| Publicado en: | Journal of Imaging Informatics in Medicine Vol. 38; no. 4; pp. 2102 - 2120 |
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| Autores principales: | , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187278977&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187278977 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 29482925 NR3A jtl: Journal of Imaging Informatics in Medicine issn: 29482925 maglogo: N pubinfo: dt: Aug2025 vid: 38 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 187278977 187278977 187278977 10.1007/s10278-024-01341-1 187278977 ppf: 2102 ppct: 18 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A Novel Self-Supervised Learning-Based Method for Dynamic CT Brain Perfusion Imaging. aug: au: Liu, Chi-Kuang Huang, Hsuan-Ming affil: https://ror.org/05d9dtr71 Department of Medical Imaging, Changhua Christian Hospital, 135 Nanxiao St., Changhua County 500, Taiwan sug: subj: Self-Directed Learning Brain Radiography Perfusion Imaging Tomography, X-Ray Computed Convolutional Neural Networks Utilization Prediction Models Methods Human Funding Source Qualitative Studies Comparative Studies Computer Simulation Image Processing, Computer Assisted Wilcoxon Rank Sum Test Sensitivity and Specificity Infarction Radiography Reference Databases ab: Dynamic computed tomography (CT)-based brain perfusion imaging is a non-invasive technique that can provide quantitative measurements of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT). However, due to high radiation dose, dynamic CT scan with a low tube voltage and current protocol is commonly used. Because of this reason, the increased noise degrades the quality and reliability of perfusion maps. In this study, we aim to propose and investigate the feasibility of utilizing a convolutional neural network and a bi-directional long short-term memory model with an attention mechanism to self-supervisedly yield the impulse residue function (IRF) from dynamic CT images. Then, the predicted IRF can be used to compute the perfusion parameters. We evaluated the performance of the proposed method using both simulated and real brain perfusion data and compared the results with those obtained from two existing methods: singular value decomposition and tensor total-variation. The simulation results showed that the overall performance of parameter estimation obtained from the proposed method was superior to that obtained from the other two methods. The experimental results showed that the perfusion maps calculated from the three studied methods were visually similar, but small and significant differences in perfusion parameters between the proposed method and the other two methods were found. We also observed that there were several low-CBF and low-CBV lesions (i.e., suspected infarct core) found by all comparing methods, but only the proposed method revealed longer MTT. The proposed method has the potential to self-supervisedly yield reliable perfusion maps from dynamic CT images. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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