Time–frequency and functional connectivity analysis in drug‐naive adolescents with depression based on electroencephalography using a visual cognitive task: A comparative study.
Background: Previous research studies have demonstrated cognitive deficits in adolescents with depression; however, the neuroelectrophysiological mechanisms underlying these deficits remain poorly understood. Utilizing electroencephalography (EEG) data collected during cognitive tasks, this study ap...
| Publicado en: | Journal of Child Psychology & Psychiatry Vol. 66; no. 9; pp. 1390 - 1403 |
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| Autores principales: | , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Wiley-Blackwell
Sep2025
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=187392222&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 187392222 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00219630 JYY jtl: Journal of Child Psychology & Psychiatry issn: 00219630 maglogo: Y pubinfo: dt: Sep2025 vid: 66 iid: 9 pid: 480 pub: Wiley-Blackwell artinfo: ui: 187392222 10.1111/jcpp.14154 ppf: 1390 ppct: 13 formats: tig: atl: Time–frequency and functional connectivity analysis in drug‐naive adolescents with depression based on electroencephalography using a visual cognitive task: A comparative study. aug: au: Zhang, Yaru Yang, Tingyu Jin, Xingyue Huang, Jinqiao Li, Zexuan Huang, Chunxiang Luo, Xuerong He, Yuqiong Cui, Xilong affil: Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China Department of Child Health Care, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan children's hospital), Changsha, China Department of Child and Adolescent Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo, China Department of psychology, The first affiliated hospital of Fujian Medical University, Fuzhou, China su: Cross-sectional method Task performance Mental depression Cognition Adolescence Functional connectivity Academic medical centers T-test (Statistics) Research funding Electroencephalography Severity of illness index Descriptive statistics Chi-squared test Visual perception Comparative studies Data analysis software sug: subj: Cross-sectional method Task performance Mental depression Cognition Adolescence Functional connectivity Academic medical centers T-test (Statistics) Research funding Electroencephalography Severity of illness index Descriptive statistics Chi-squared test Visual perception Comparative studies Data analysis software keyword: Adolescents depression EEG FC power spectrum Adolescents depression EEG FC power spectrum ab: Background: Previous research studies have demonstrated cognitive deficits in adolescents with depression; however, the neuroelectrophysiological mechanisms underlying these deficits remain poorly understood. Utilizing electroencephalography (EEG) data collected during cognitive tasks, this study applies time–frequency analysis and functional connectivity (FC) techniques to explore the neuroelectrophysiological alterations associated with cognitive deficits in adolescents with depression. Methods: A total of 173 adolescents with depression and 126 healthy controls (HC) participated in the study, undergoing EEG while performing a visual oddball task. Delta, theta, and alpha power spectra, along with FC, were calculated and analyzed. Results: Adolescents with depression exhibited significantly reduced delta, theta, and alpha power at the Fz, Cz, C5, C6, Pz, P5, and P6 electrodes compared to the HC group. Notably, theta power at the F5 electrode and alpha power at the F5 and F6 electrodes were significantly lower in the depression group than in the HC group. Additionally, cortical FC in the frontal and central regions was markedly decreased in adolescents with depression compared to HC. Conclusions: During cognitive tasks, adolescents with depression display distinct abnormalities in both high‐ and low‐frequency brain oscillations, as well as reduced functional connectivity in the frontal, central, and parietal regions compared to HC. These findings offer valuable neuroelectrophysiological insights into the cognitive deficits associated with adolescent depression. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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