A Brief Review of Cancer Treatment and DNA Damage Using Auger Effect or Low-Energy Electrons.
Introduction: Despite advances in cancer therapy, many treatments result in significant side effects and inconsistent remission. This review was aimed at exploring the potential of Auger electrons (AEs) as a novel, highly localized approach to cancer treatment. Materials & Methods: Relevant studies...
| Publicado en: | Journal of Basic Research in Medical Sciences Vol. 12; no. 3; pp. 17 - 30 |
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| Autores principales: | , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Ilam University of Medical Sciences
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187399446&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187399446 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23830506 N1MR jtl: Journal of Basic Research in Medical Sciences issn: 23830506 maglogo: N pubinfo: dt: 2025 vid: 12 iid: 3 pid: 63388 pub: Ilam University of Medical Sciences artinfo: ui: 187399446 187399446 187399446 187399446 ppf: 17 ppct: 13 formats: fmt: @attributes: type: P tig: atl: A Brief Review of Cancer Treatment and DNA Damage Using Auger Effect or Low-Energy Electrons. aug: au: Emami-Razavi, Mohsen Dezfouli, Sarina Abbasi affil: Department of Physics, College of Converging Sciences and Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran. sug: subj: Neoplasms Radiotherapy Electrons Therapeutic Use Radioisotopes Therapeutic Use Radiopharmaceuticals Therapeutic Use DNA Damage Drug Effects Cell Line, Tumor Drug Effects Cell Death Drug Effects Molecular Structure Tumor Cells, Cultured Spectrum Analysis Nanotechnology Molecular Imaging Neoplasm Invasiveness Prevention and Control Neoplasm Metastasis Prevention and Control Radionuclide Imaging Neoplasm Recurrence, Local Prevention and Control ab: Introduction: Despite advances in cancer therapy, many treatments result in significant side effects and inconsistent remission. This review was aimed at exploring the potential of Auger electrons (AEs) as a novel, highly localized approach to cancer treatment. Materials & Methods: Relevant studies were reviewed to examine the mechanism of action of AEs emitted from radioisotopes, their DNA-damaging effects, and their selective activity in cancer cells. The analysis also included recent developments in cancer cell detection based on surface charges, radionuclide delivery systems, and the role of proton tunneling and low-energy electrons in DNA disruption. Results: Auger electrons, characterized by low energy and high linear energy transfer (LET), induce lethal DNA damage with minimal impact on surrounding healthy tissue. They act through direct DNA interaction or indirectly via water ionization. Detection methods based on cell surface charge properties showed promise in improving cancer cell targeting. Additionally, advancements in radionuclide carriers enhanced delivery precision. Insights into proton tunneling supported the biological relevance of low-energy electrons in therapeutic applications. Conclusion: Auger electron therapy offers a promising, targeted strategy for cancer treatment with reduced collateral damage. Continued research is needed to refine delivery systems and better understand electron-cell interactions to maximize therapeutic outcomes. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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