Recent advances of trichosanthin and its role in diseases.
Trichosanthin (TCS), as an alkaline plant-protein classified as a type I ribosome-inactivating protein (RIP), is squeezed out of traditional medicinal plant Trichosanthes kirilowii. Unlike type II RIPs characterized by dual polypeptide chains, TCS exhibits significantly lower cytotoxicity while main...
| Publicado en: | Fitoterapia Vol. 185 |
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| Autores principales: | , , |
| Formato: | review Journal Article |
| Publicado: |
Elsevier B.V.
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187412481&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187412481 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0367326X JF4 jtl: Fitoterapia issn: 0367326X maglogo: N pubinfo: dt: Sep2025 vid: 185 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 187412481 187412481 187412481 10.1016/j.fitote.2025.106695 187412481 ppct: 1 formats: tig: atl: Recent advances of trichosanthin and its role in diseases. aug: au: He, Bin Yao, Hangping Zhang, Xiaoqian affil: Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou 310003, China sug: subj: Antiviral Agents Analysis Antiviral Agents Pharmacodynamics Melon Analysis Plant Proteins Analysis Plant Proteins Pharmacodynamics Biochemical Phenomena Crystallography Drug Delivery Systems Molecular Structure Plants, Medicinal Analysis Apoptosis Signal Transduction Antineoplastic Agents Pharmacodynamics Antiinflammatory Agents Pharmacodynamics Toxicity Tests Nanomedicine Neoplasms Therapy Virus Diseases Therapy Nervous System Diseases Therapy ab: Trichosanthin (TCS), as an alkaline plant-protein classified as a type I ribosome-inactivating protein (RIP), is squeezed out of traditional medicinal plant Trichosanthes kirilowii. Unlike type II RIPs characterized by dual polypeptide chains, TCS exhibits significantly lower cytotoxicity while maintaining potent antiviral activity. These distinctive pharmacological properties have driven growing interest in its therapeutic potential, with accelerating research efforts spanning mechanistic studies, structural optimization, and clinical trials in recent decades. This review will systematically evaluate three critical aspects of TCS research: (1) structure-activity relationships based on crystallographic studies; (2) molecular mechanisms underlying its biological effects; (3) pharmacological properties of TCS and clinical applications of including immunogenicity and delivery optimization. Through critical analysis of recent advances, we aim to identify key knowledge gaps and propose novel strategies for harnessing this plant-derived protein in precision medicine and gain more insight into the mechanism of this natural plant-protein. [Display omitted] • Trichosanthin (TCS) is derived from Trichosanthes kirilowii with lower cytotoxicity and notable pharmacological properties. • TCS exhibits potent antiviral activity, antitumor activity and immunogenicity. • This review aims to identify key knowledge gaps and propose novel strategies for TCS in clinical application. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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