Meta-analysis of the Effect of Semaglutide on Blood Pressure in Obese Populations.
Objective: The aim was to systematically evaluate the effect of semaglutide on blood pressure in obese populations using meta-analysis methods. Methods: Randomized controlled trials on the effect of semaglutide on blood pressure regulation published from the inception of the databases to October 202...
| Publicado en: | American Journal of Cardiovascular Drugs Vol. 25; no. 5; pp. 655 - 666 |
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| Autores principales: | , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187534208&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187534208 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11753277 G7S jtl: American Journal of Cardiovascular Drugs issn: 11753277 maglogo: N pubinfo: dt: Sep2025 vid: 25 iid: 5 pid: 87227 pub: Springer Nature artinfo: ui: 187534208 185830753 187534208 187534208 10.1007/s40256-025-00738-9 187534208 ppf: 655 ppct: 11 formats: tig: atl: Meta-analysis of the Effect of Semaglutide on Blood Pressure in Obese Populations. aug: au: Li, Yihan Xue, Kefan Hu, Rui Hu, Xiao Guo, Ran Guo, Hongxia Li, Gang affil: https://ror.org/01nv7k942 Division of Cardiology, Institute of Geriatric Diseases, Hebei General Hospital, Shijiazhuang, Hebei, China sug: subj: Glucagon-Like Peptide-1 Receptor Agonists Therapeutic Use Antiobesity Agents Therapeutic Use Obesity Drug Therapy Hypertension Prevention and Control Systolic Pressure Drug Effects Diastolic Pressure Drug Effects Drug Efficacy Evaluation Human Systematic Review Meta Analysis Male Female Adult Middle Age Aged Aged, 80 and Over Funding Source PubMed Embase Cochrane Library Data Analysis Software Descriptive Statistics Confidence Intervals Diabetic Patients Glucagon-Like Peptide-1 Receptor Agonists Administration and Dosage Dose-Response Relationship, Drug Antihypertensive Agents Hypoglycemic Agents Weight Control Glucagon-Like Peptide-1 Receptor Agonists Pharmacodynamics Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Objective: The aim was to systematically evaluate the effect of semaglutide on blood pressure in obese populations using meta-analysis methods. Methods: Randomized controlled trials on the effect of semaglutide on blood pressure regulation published from the inception of the databases to October 2024 were searched for in PubMed, Embase, the Cochrane Library, and Web of Science. Stata software was used for statistical analysis of the outcome measures in all included studies. Egger's test was applied to assess the risk of publication bias. Results: A total of 22 studies involving 15,347 participants were included in this meta-analysis. The results showed that, compared to the control group, the semaglutide group significantly reduced systolic blood pressure (SBP) (mean difference [MD] − 2.90, 95% confidence interval [CI] − 3.70 to − 2.11; P < 0.01) and diastolic blood pressure (DBP) (MD − 0.86, 95% CI − 1.34 to − 0.38; P < 0.01). Further subgroup analysis revealed that, compared to diabetic populations, semaglutide had a more significant reduction in SBP (− 1.87, 95% CI − 2.67 to − 1.06, vs − 5.02, 95% CI − 6.10 to − 3.94) and DBP (− 0.43, 95% CI − 0.89 to 0.02, vs − 1.96, 95% CI − 3.12 to − 0.80) in non-diabetic populations. The higher dose of semaglutide (2.4 mg) was found to significantly lower SBP (MD − 4.31, 95% CI − 5.18 to − 3.44) and DBP (MD − 1.84, 95% CI − 2.70 to − 0.98), although mild heterogeneity was present. Sensitivity analysis showed that the exclusion of any single study did not significantly affect the final results. Conclusion: Current evidence suggests that semaglutide can lower SBP and DBP, and increasing the dosage can enhance the blood pressure-lowering effect. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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