A Review on the Evolving Role of Radiation Therapy in the Treatment of Locally Advanced Rectal Cancer.
Simple Summary: This review discusses the recent developments in the treatment of microsatellite-stable locally advanced rectal cancer (LARC), focusing on the evolving role of radiation therapy as part of total neoadjuvant therapy (TNT). It highlights the importance of incorporating both tumor- and...
| Publicado en: | Current Oncology Vol. 32; no. 8; pp. 443 - 468 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
MDPI
Aug2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187557452&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187557452 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11980052 5EKK jtl: Current Oncology issn: 11980052 maglogo: N pubinfo: dt: Aug2025 vid: 32 iid: 8 pid: 97109 pub: MDPI artinfo: ui: 187557452 10.3390/curroncol32080443 187557452 ppf: 443 ppct: 25 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A Review on the Evolving Role of Radiation Therapy in the Treatment of Locally Advanced Rectal Cancer. aug: au: Dandash, Zeinab Mobayed, Tala Temraz, Sally Shamseddine, Ali Doughan, Samer Deeba, Samer Ayoub, Zeina Eid, Toufic Youssef, Bassem Hilal, Lara affil: Department of Radiation Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon sug: ab: Simple Summary: This review discusses the recent developments in the treatment of microsatellite-stable locally advanced rectal cancer (LARC), focusing on the evolving role of radiation therapy as part of total neoadjuvant therapy (TNT). It highlights the importance of incorporating both tumor- and patient-specific factors, along with a thorough discussion regarding individual patient preferences, in determining the best treatment approach. This may range from dose-escalated non-operative radiation therapy to the omission of radiation altogether in select patients. Treatment of locally advanced rectal cancer (LARC), clinical stages II–III, typically involves multimodal treatment options. Over the past decade, the role of radiation therapy as a neoadjuvant treatment for LARC has evolved and is currently a part of total neoadjuvant therapy (TNT). Some recently published studies advocate for the omission of radiation therapy entirely, while others report on a non-operative approach that emphasizes the use of higher radiation therapy doses. This review aims to evaluate the latest literature on the current role of radiation therapy in the management of LARC, with a discussion of how to best select the most appropriate treatment protocol based on individual patient and tumor characteristics, comorbidities, and personal needs and preferences. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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