Heritable Tissue‐Specific Gene Expression Associates With Chronic Wound Microbial Species.
The reasons for interpatient variability in chronic wound microbiome composition are thought to be complex but are poorly known. To investigate how patients' genetically regulated tissue expression may influence chronic wound bacterial composition, we performed a microbiome‐transcriptome‐wide associ...
| Publicado en: | Wound Repair & Regeneration Vol. 33; no. 4; pp. 1 - 15 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jul/Aug2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187573141&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187573141 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Jul/Aug2025 vid: 33 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 187573141 187573141 187573141 10.1111/wrr.70055 187573141 ppf: 1 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Heritable Tissue‐Specific Gene Expression Associates With Chronic Wound Microbial Species. aug: au: Omeir, Khalid Ancira, Jacob Gabrilska, Rebecca Tipton, Craig Miller, Clint Noe, Ashley Subasinghe, Kumudu Rowe, Megan Phillips, Nicole Wolcott, Joseph Philips, Caleb D. affil: Department of Biological Sciences, Texas Tech University, Lubbock Texas,, USA sug: subj: Wounds, Chronic Familial and Genetic Wounds, Chronic Microbiology Gene Expression Physiology Microbiota Physiology Funding Source Human DNA Genotype Descriptive Statistics Bacterial Colonization Bacterial Infections ab: The reasons for interpatient variability in chronic wound microbiome composition are thought to be complex but are poorly known. To investigate how patients' genetically regulated tissue expression may influence chronic wound bacterial composition, we performed a microbiome‐transcriptome‐wide association study. This approach involved estimating for 509 patients their tissue‐specific gene expression from DNA genotypes, followed by associating gene expression to the relative abundances of species detected in their wounds as provided on clinical reports to the physician. Comparisons to artery, blood, fibroblast, skeletal muscle, skin, subcutaneous fat, and nerve tissue resulted in 251 transcriptional differences at 109 genes significantly explaining abundances of 39 different species. Overall, these species were detected in ~63% of wounds. A similar number of associations per tissue was observed (range 31–39), and many genes were associated at multiple tissues in distinct ways. The cumulative variance across loci for species relative abundance explained ranged from ~5%–36%, depending on species. Although the same gene was almost never associated with more than one species, ~14% of enriched pathways were independently enriched for multiple species, which may reflect the diversity of ways microbes interact with partially overlapping attributes of the wound bed. Commonly enriched pathways pertained to collagen formation and modification, cell signalling, cytoskeletal dynamics, interactions with extracellular matrix, transmembrane proteins, amongst others. This work expands the new perspective that individual genetics may partially determine microbial colonisation and infection. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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