Evidence‐Based Approaches to Quality Improvement: A Narrative Review of Integrating Bayesian Adaptive Trials Into Health Services.

Rationale: Quality improvement (QI) in health service programmes aims to make small, incremental changes to increase reach and efficiency. Simple, low‐risk programmatic changes can improve services, particularly when supported by robust evidence. However, in health service contexts, there is tension...

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Publicado en:Journal of Evaluation in Clinical Practice Vol. 31; no. 5; pp. 1 - 12
Autores principales: Kim, Min Jung, Prieto‐Merino, David, Nicholas, Jennifer, Allen, Luke, Burton, Matthew J., Bastawrous, Andrew, Macleod, David
Formato: review Journal Article
Publicado: Wiley-Blackwell Aug2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Aug2025
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        10.1111/jep.70197
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        atl: Evidence‐Based Approaches to Quality Improvement: A Narrative Review of Integrating Bayesian Adaptive Trials Into Health Services.
      aug:
        au:
          Kim, Min Jung
          Prieto‐Merino, David
          Nicholas, Jennifer
          Allen, Luke
          Burton, Matthew J.
          Bastawrous, Andrew
          Macleod, David
        affil: Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK
      sug:
        subj:
          Quality Improvement
          Health Services Research
          Implementation Science
          Probability
          Medical Practice, Evidence-Based
          Study Design
          Clinical Trials
      ab: Rationale: Quality improvement (QI) in health service programmes aims to make small, incremental changes to increase reach and efficiency. Simple, low‐risk programmatic changes can improve services, particularly when supported by robust evidence. However, in health service contexts, there is tension between the need for swift decision‐making and the high research standards for conducting methodologically rigorous trials. Randomized trials are rarely used to evaluate these changes due to high costs and long timelines, especially when the changes are expected to result in marginal improvements. Instead, health service programmes frequently introduce changes informed by anecdotal evidence or less robust evaluation methods such as before‐and‐after comparisons. Aims: In this paper, we present a narrative review of the concepts underlying Bayesian adaptive trial designs for conducting QI research, highlighting their use in the commercial sector and exploring opportunities for cross‐industry learning and future application in healthcare settings. Methods: Relevant studies were selected based on their contextual relevance to the topic, in keeping with the narrative review approach. Results: Given that programmatic changes typically yield modest improvements, we recommend that adaptive trial designs can strike a balance between obtaining reliable results and avoiding overly large sample sizes. We review how interim analysis and early stopping can be integrated into trials, allowing the level of rigour to be adjusted according to the proramme specifications. Conclusion: Adaptive trial designs hold significant promise for enhancing the QI efforts. To ensure that adaptive trial designs can be successfully integrated into health service contexts, tradeoffs should be made between methodological rigour and resource constraints.
      pubtype: Academic Journal
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        Journal Article
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    language: English
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