Alterations in microarchitecture and network integrity in diffusion tensor images of children with marginal intelligence or intellectual disabilities.
Purpose: To investigate damage to fiber bundles and brain networks in children with marginal intelligence (MI) or intellectual disability (ID) by using Diffusion Tensor Imaging (DTI) sequences. Methods: Thirty healthy children, 25 with MI, 35 with ID, and 32 with both ID and attention deficit hypera...
| Publicado en: | Neuroradiology Vol. 67; no. 7; pp. 1837 - 1848 |
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| Autores principales: | , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187625123&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187625123 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Jul2025 vid: 67 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 187625123 184318253 187625123 187625123 10.1007/s00234-025-03608-y 187625123 ppf: 1837 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Alterations in microarchitecture and network integrity in diffusion tensor images of children with marginal intelligence or intellectual disabilities. aug: au: Liu, Zhenghua Wang, Ya Yao, Ruowei Li, Jiani affil: The Radiology Department, The Dongguan Maternal and Child Health Care Hospital, DongGuan City, China sug: subj: Brain Abnormalities Neural Pathways Physiopathology Intelligence In Infancy and Childhood Persons with Intellectual Disabilities In Infancy and Childhood Magnetic Resonance Imaging Methods Human Male Female Child Case Control Studies Attention Deficit Hyperactivity Disorder Intelligence Tests DSM Multiple Linear Regression Models, Statistical Data Analysis Software Chi Square Test Analysis of Variance Post Hoc Analysis Unpaired T-Tests Analysis of Covariance Spearman's Rank Correlation Coefficient Gray Matter White Matter Cerebrospinal Fluid Functional Connectivity Children with Disabilities Child: 6-12 years Male Female ab: Purpose: To investigate damage to fiber bundles and brain networks in children with marginal intelligence (MI) or intellectual disability (ID) by using Diffusion Tensor Imaging (DTI) sequences. Methods: Thirty healthy children, 25 with MI, 35 with ID, and 32 with both ID and attention deficit hyperactivity disorder (ADHD) underwent 3.0 T MRI scans, including DTI sequences. Analysis of the DTI data yielded correlation tractography, network measures, and graph visualizations. Results: Children with MI, ID or both ID and ADHD have damage in the bilateral arcuate fasciculi, bilateral superior longitudinal fasciculi and thalamic radiations, corpus callosum's body, and right corticostriatal tracts. Furthermore, both the MI and ID-ADHD groups were affected in the right parietal aslant tract, bilateral corticospinal tracts, and bilateral medial lemnisci, which were not affected in patients with ID alone. The MI, ID and ID-ADHD groups exhibited a significantly lower density, global efficiency, and rich club coefficient than the controls. Patients with MI, ID, or both ID and ADHD had no nodes in the bilateral middle and inferior frontal gyri. Moreover, individuals with ID, alone or combined with ADHD, also lacked nodes in the bilateral temporal lobes. Conclusion: Children with MI, ID, or comorbid ID and ADHD exhibited significant morphological abnormalities in fiber tracts, substantial reductions in fiber bundle volumes, and disrupted neural network connectivity. Furthermore, graph visualizations of the connectome reveal a progressive increase in the defect of hub nodes, worsening from MI to ID, whether alone or in conjunction with ADHD, when compared to normal controls. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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