Vitamin K Nutritional Status and Disease Risk - A Mendelian Randomization Analysis.
Vitamin K is an essential nutrient obtained from dietary sources and commonly included in mainstream dietary supplements, playing a key role in regulating physiological functions and maintaining overall health. However, the causal nature of such associations between vitamin K nutritional status and...
| Published in: | Journal of Dietary Supplements Vol. 22; no. 5; pp. 775 - 795 |
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| Main Authors: | , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Taylor & Francis Ltd
2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187638154&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187638154 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19390211 2Y62 jtl: Journal of Dietary Supplements issn: 19390211 maglogo: N pubinfo: dt: 2025 vid: 22 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 187638154 187018341 187638154 187638154 10.1080/19390211.2025.2538485 187638154 ppf: 775 ppct: 20 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Vitamin K Nutritional Status and Disease Risk - A Mendelian Randomization Analysis. aug: au: Qu, Yundan Zhao, Si Cai, Xinhe Huang, Hanxue Xie, Pan Peng, Jingbo Zhang, Wei Zhou, Honghao Li, Xi Chen, Yi Zhang, Yu affil: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China sug: subj: Vitamin K Nutritional Status Risk Assessment Mendelian Randomization Vitamin K Deficiency Complications Chronic Disease Risk Factors Biological Markers Human Cardiovascular Diseases Musculoskeletal Diseases Liver Diseases Neoplasms Genome Wide Association Study Causality Chronic Disease Prevention and Control Dietary Supplementation Chronic Disease Pathology Research, Medical Funding Source Chronic Disease Diagnosis Chronic Disease Prognosis Odds Ratio Confidence Intervals Descriptive Statistics ab: Vitamin K is an essential nutrient obtained from dietary sources and commonly included in mainstream dietary supplements, playing a key role in regulating physiological functions and maintaining overall health. However, the causal nature of such associations between vitamin K nutritional status and diseases remains obscure. The existence of causality helps to prove the possibility of vitamin K becoming a biomarker for predicting susceptibility to certain diseases. To investigate this hypothesis, we conducted a literature review to identify diseases previously reported to be associated with vitamin K nutritional status, including cardiovascular, musculoskeletal, liver diseases and cancer, as candidate outcome factors. We also selected specific vitamin K subtypes with distinct physiological functions as exposure factors. Subsequently, we utilized a two-sample Mendelian randomization (MR) analysis using publicly available genome-wide association studies (GWAS) statistics to clarify causal relationships and distinguish vitamin K's role as a risk factor or protective factor for these diseases. Our results showed that genetically predicted circulating vitamin K1 levels were positively associated with ischemic heart disease, myocardial infarction, heart failure, and alcoholic liver disease (ALD) risk, and negatively associated with lung carcinoma risk. Additionally, matrix Gla protein (MGP), as a biomarker of vitamin K2 nutritional status, was found to be positively associated with the risk of breast carcinoma and ALD. Osteocalcin (OC), another vitamin K2 biomarker, was potentially protective against nonalcoholic fatty liver disease (NAFLD). This novel causality discovery highlighted the necessity for further exploration of vitamin K nutritional status as a crucial factor in the pathogenesis and potential as a predictive, diagnostic, and prognostic biomarker for disease, including carcinoma, liver disease, myocardial infarction, heart failure, and related disorders. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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