The association between maternal diabetes and the risk of attention deficit hyperactivity disorder in offspring: an updated systematic review and meta-analysis.
Mixed results have been reported regarding the link between different types of maternal diabetes and attention deficit hyperactivity disorder (ADHD) in offspring. Hence, we conducted a systematic review and meta-analysis to explore these associations. Relevant studies on the subject were retrieved f...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 8; pp. 2417 - 2430 |
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| Autores principales: | , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187670745&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187670745 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Aug2025 vid: 34 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 187670745 182498507 187670745 187670745 10.1007/s00787-025-02645-5 187670745 ppf: 2417 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The association between maternal diabetes and the risk of attention deficit hyperactivity disorder in offspring: an updated systematic review and meta-analysis. aug: au: Damtie, Yitayish Dachew, Berihun Assefa Ayano, Getinet Tadesse, Abay Woday Betts, Kim Alati, Rosa affil: https://ror.org/02n415q13 School of Population Health, Faculty of Health Sciences, Curtin University, Bentley, WA, Australia sug: subj: Diabetes Mellitus, Gestational Complications Diabetes Mellitus, Type 1 Complications Diabetes Mellitus, Type 2 Complications Attention Deficit Hyperactivity Disorder Risk Factors Risk Assessment Human Male Female Pregnancy Systematic Review Meta Analysis PubMed Medline Embase CINAHL Database Psycinfo Descriptive Statistics Checklists Child Child: 6-12 years Male Female ab: Mixed results have been reported regarding the link between different types of maternal diabetes and attention deficit hyperactivity disorder (ADHD) in offspring. Hence, we conducted a systematic review and meta-analysis to explore these associations. Relevant studies on the subject were retrieved from six major databases, including PubMed, Medline, Embase, Scopus, CINAHL, and PsychINFO. The methodological quality of the included studies was evaluated using the Newcastle-Ottawa Scale, and between-study heterogeneity was assessed using the I2 statistic. Subgroup, sensitivity, and meta-regression analyses were conducted to identify the sources of heterogeneity between studies. In total, seventeen observational studies (five case-control and twelve cohort studies) with 18,063,336 study participants were included in the final analysis. Our random-effects meta-analysis revealed that exposure to any form of maternal diabetes was associated with an increased risk of ADHD in children. Specifically, we observed a heightened risk of ADHD in children exposed to gestational diabetes mellitus, any pre-existing diabetes, pre-existing type 1 diabetes mellitus, and type 2 diabetes mellitus. Our study suggests that children exposed to diabetes during prenatal development are at a higher risk of developing ADHD. These findings underscore the critical importance of early screening and timely interventions for exposed offspring. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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