Functional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia.
Background: The role of functional connectivity (FC) changes in the prefrontal-thalamic-cerebellar circuit in schizophrenia has received widespread attention. Currently, domestic and international studies on this circuit have focused on adults, while the FC of this circuit in the brains of adolescen...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 8; pp. 2463 - 2473 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187670751&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187670751 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Aug2025 vid: 34 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 187670751 182898763 187670751 187670751 10.1007/s00787-025-02656-2 187670751 ppf: 2463 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Functional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia. aug: au: Song, Yichen Zhu, HanYu Wu, Zhaoyang Hu, Wenyan Zhang, Sen Zhou, Youqi Peng, Yue Yang, Yongfeng Li, Wenqiang Shi, Han Yang, Ge Zhang, Yan Lv, Luxian affil: https://ror.org/038hzq450 Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 453002, Xinxiang, China sug: subj: Schizophrenia In Adolescence Prefrontal Cortex Physiopathology Cerebellum Physiopathology Thalamus Physiopathology China Funding Source Human Adolescence Academic Medical Centers China Comparative Studies Magnetic Resonance Imaging Neural Pathways Cognition Scales T-Tests Pearson's Correlation Coefficient Data Analysis Software Descriptive Statistics Adolescent: 13-18 years ab: Background: The role of functional connectivity (FC) changes in the prefrontal-thalamic-cerebellar circuit in schizophrenia has received widespread attention. Currently, domestic and international studies on this circuit have focused on adults, while the FC of this circuit in the brains of adolescent patients with schizophrenia (AOS) has been less reported. Methods: We recruited 124 subjects who underwent resting-state functional magnetic resonance imaging scans at baseline, using key brain regions in the prefrontal-thalamic-cerebellar circuit as seed regions, to investigate the FC in AOS versus healthy controls. The FC of this loop was compared with that of the whole brain in healthy controls. Results: Compared to healthy controls, patients with AOS had reduced FC between the medial prefrontal cortex (mPFC) and precuneus (PCu) and between the posterior cerebellar lobe and middle temporal gyrus. Reduced FC between the left mPFC and the left PCu in patients with AOS was associated with positive symptom scores on the PANSS and was positively correlated with the Symbolic Encoding Scale, the Maze Scale, and the Category Fluency Test Scale. Reduced FC between the right posterior cerebellar lobe and the right middle temporal gyrus is positively correlated with the simple visuospatial memory test in AOS patients. Conclusions: There are FC abnormalities in the prefrontal-thalamic-cerebellar circuit, precuneus, and temporal lobe in AOS. These abnormalities appear in the early stages of schizophrenia, independent of medication, and are characteristic of the disorder. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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