Evidence for brain glial activity in chronic migraine patients: a [11C] PBR28 PET/MR study.
Purpose: Although neuroinflammation may play a key role in the pathology of migraine and its progression to chronic migraine (CM), its specific involvement-particularly the role of microglia- remains unclear. We investigated whether neuroinflammation is involved in the pathophysiology of CM and whet...
| Published in: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 52; no. 11; pp. 4334 - 4345 |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Sep2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187672859&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187672859 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Sep2025 vid: 52 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 187672859 184968122 10.1007/s00259-025-07282-3 187672859 ppf: 4334 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Evidence for brain glial activity in chronic migraine patients: a [11C] PBR28 PET/MR study. aug: au: Chang, Yan Zhang, Xiwan Xiao, Shaobo Liu, Jiajin Wang, Yuan Song, Jingbin Fu, Huaping Li, Yungang Su, Hui Yi, Huijie Su, Wenjie Gao, Nan Zhao, JinJing Wang, Ruimin Liu, Ruozhuo affil: https://ror.org/05tf9r976 Medical School of Chinese PLA, 100853, Beijing, China sug: ab: Purpose: Although neuroinflammation may play a key role in the pathology of migraine and its progression to chronic migraine (CM), its specific involvement-particularly the role of microglia- remains unclear. We investigated whether neuroinflammation is involved in the pathophysiology of CM and whether pro-inflammatory signals are associated with its clinical features. Methods: Nineteen individuals with CM and 10 healthy controls (HCs) underwent integrated brain positron emission tomography (PET)/magnetic resonance (MR) using the translocator protein (TSPO) radioligand ([11C] PBR28, a marker of glial activation, together with the quantification of blood plasma inflammatory cytokine/chemokine. Volumes in regions of interest (ROI) were calculated based on MRI data and the standardized uptake value ratio (SUVR) for [11C] PBR28 was extracted for each ROI. The Spearman's rank correlation coefficient between [11C] PBR28 SUVR and changes in plasma factors was calculated. Results: CM patients had a significantly higher Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA) scores than that in HCs (p < 0.05). Participants with CM also exhibited reduced volume in the thalamus (p = 0.012), compared with HCs. Moreover [11C] PBR28 binding was increased in the midbrain, occipital lobe and vermis, along with increased interictal plasma interleukin-8 (IL-8) and CX3CL1 levels, in individuals with CM compared with HCs. Notably, the midbrain levels of TSPO were negatively correlated with the headache frequency (r=-0.462, p = 0.046). Conclusions: These findings demonstrate increased central inflammation in CM participants compared to HCs, providing imaging evidence for the potential involvement of neuroinflammation in CM pathophysiology. Additionally, the observed reduction in thalamic volume may contribute to the chronification of migraine. Clinical trial number: Not applicable. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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