Lauric Acid Promotes Esophageal Squamous Cell Carcinoma via GPR84: Lipid Metabolic Dysregulation as a Therapeutic Target.
Various studies have demonstrated metabolic disorders in patients with esophageal squamous cell carcinoma (ESCC), although their potential role in ESCC development remains unclear. Here, we investigated alterations in the serum and fecal metabolomes of 23 ESCC patients and 23 healthy controls using...
| Publicado en: | Nutrition & Cancer Vol. 77; no. 9; pp. 1074 - 1089 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187695851&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187695851 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2025 vid: 77 iid: 9 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 187695851 186871796 187695851 187695851 10.1080/01635581.2025.2535053 187695851 ppf: 1074 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Lauric Acid Promotes Esophageal Squamous Cell Carcinoma via GPR84: Lipid Metabolic Dysregulation as a Therapeutic Target. aug: au: Shen, Weitao Li, Nan Zhang, Anqi Quan, MengJie Cao, Jing Qian, Qiliu Tang, Derong Hu, Jian Lin, Qiang affil: Department of Oncology, North China Petroleum Bureau General Hospital, Hebei Medical University, Renqiu, China sug: subj: Fatty Acids Adverse Effects Esophageal Squamous Cell Carcinoma Risk Factors Receptors, Cell Surface Adverse Effects Lipids Metabolism Metabolomics Risk Assessment Tumor Markers, Biological Human Feces Analysis Metabolites In Vitro Studies Cell Line, Tumor Chromatography, High Pressure Liquid Signal Transduction Linear Regression Polymerase Chain Reaction Flow Cytometry Apoptosis Cell Cycle Descriptive Statistics Mann-Whitney U Test Data Analysis Software Steroids Metabolism Gene Expression Cell Viability Funding Source ab: Various studies have demonstrated metabolic disorders in patients with esophageal squamous cell carcinoma (ESCC), although their potential role in ESCC development remains unclear. Here, we investigated alterations in the serum and fecal metabolomes of 23 ESCC patients and 23 healthy controls using untargeted metabolomics. Further analysis identified lauric acid as a biomarker for ESCC through targeted metabolomics, with validation in 88 ESCC patients and 44 healthy controls. Then, we examined the effects and mechanisms of lauric acid on EC109 cell physiological functions. Significant alterations occurred in serum and fecal samples from ESCC patients versus healthy controls, with lipid metabolites and associated pathways showing the most pronounced changes. Lauric acid was identified as a characteristic altered metabolite and an independent risk factor for ESCC (OR = 1.71, 95% CI: 1.05–2.79, p < 0.05). Mechanistic studies demonstrated that lauric acid promotes EC109 survival, invasion, and migration by interacting with the highly expressed fatty acid receptor GPR84 in ESCC tissues. Our research provides new insights into the relationship between lipid metabolism disorders and ESCC development, suggesting that lauric acid serves as an ESCC risk factor and may offer therapeutic intervention avenues. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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