Anti-colorectal cancer effect and mechanism of a polysaccharide from Ruditapes philippinarum.
Purpose: Colorectal cancer (CRC) is the most common malignant tumor with a persistently high mortality rate worldwide. This study aimed to explore the anti-CRC effect and mechanisms of Ruditapes philippinarum polysaccharides (RPP). Methods: We used HT-29 cells and HT-29 tumor-bearing mice to study t...
| Publicado en: | European Journal of Nutrition Vol. 64; no. 6; pp. 1 - 15 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187803096&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187803096 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Sep2025 vid: 64 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 187803096 10.1007/s00394-025-03794-8 187803096 ppf: 1 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Anti-colorectal cancer effect and mechanism of a polysaccharide from Ruditapes philippinarum. aug: au: Zhang, Xinyu Liu, Mengyue Zhang, Xuemei Du, Zubo Wei, Yuxi Li, Fei affil: https://ror.org/021cj6z65 College of Life Science, Qingdao University, 308 Ningxia Road, 266071, Qingdao, China sug: ab: Purpose: Colorectal cancer (CRC) is the most common malignant tumor with a persistently high mortality rate worldwide. This study aimed to explore the anti-CRC effect and mechanisms of Ruditapes philippinarum polysaccharides (RPP). Methods: We used HT-29 cells and HT-29 tumor-bearing mice to study the anti-CRC effects and mechanisms of RPP in vitro and in vivo. Results: Animal experiments demonstrated that RPP-treated groups increased expression levels of Bax and cleaved caspase-3 proteins while reducing expression levels of Bcl-2 and Clusterin proteins in mice bearing HT-29 tumors. These results suggested the potential involvement of the mitochondrial apoptotic pathway in HT-29 cells apoptosis. Meanwhile, expression levels of β-catenin and its subsequent target proteins, such as Survivin, C-myc, and Cyclin D1, were suppressed, suggesting that RPP arrested the cell cycle of HT-29 cells in the G0/G1 phase by inhibiting the Wnt/β-catenin pathway. Additionally, RPP suppressed levels of TNF-α, IL-6, and IL-1β, and then alleviated the inflammatory response. Conclusion: Overall, these findings could provide a new insight that RPP are promising polysaccharides to combat CRC as drugs or preventive health products. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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