Effectiveness and Safety of Intramyocardial Needle Ablation for Refractory Ventricular Tachycardia and Premature Ventricular Complexes: A Systematic Review and Meta‐Analysis.
Introduction: Intramyocardial needle ablation is a novel technique for treating refractory ventricular tachycardia (VT) and premature ventricular complexes (PVC). However, studies defining the effectiveness and safety of this procedure are limited. This meta‐analysis aims to evaluate the safety and...
| Publicado en: | Journal of Cardiovascular Electrophysiology Vol. 36; no. 9; pp. 2279 - 2287 |
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| Autores principales: | , , , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187860115&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187860115 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10453873 GSB jtl: Journal of Cardiovascular Electrophysiology issn: 10453873 maglogo: Y pubinfo: dt: Sep2025 vid: 36 iid: 9 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 187860115 186584343 187860115 187860115 10.1111/jce.70000 187860115 ppf: 2279 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Effectiveness and Safety of Intramyocardial Needle Ablation for Refractory Ventricular Tachycardia and Premature Ventricular Complexes: A Systematic Review and Meta‐Analysis. aug: au: Gupta, Kartik Qureshi, Muhammad Ahmad Rawlley, Bharat Jain, Vardhmaan Verma, Atul Siontis, Konstantinos C. Deskhmukh, Abhishekh Khan, Arfaat Raad, Mohamad affil: Edith and Benson Ford Heart and Vascular Institute, Division of Cardiovascular Diseases, Henry Ford Hospital, Detroit Michigan,, USA sug: subj: Ablation Techniques Catheter Ablation Tachycardia, Ventricular Surgery Premature Ventricular Contractions Surgery Patient Safety Evaluation Treatment Outcomes Evaluation Ablation Techniques Evaluation Action Potentials Evaluation Needles Utilization Recurrence Risk Factors Risk Assessment Human Male Female Middle Age Aged Systematic Review Meta Analysis Heart Rate Time Factors Ventricular Ejection Fraction Physiology Fluoroscopy Embase Medline Checklists Age Factors Sex Factors Antiarrhythmia Agents Therapeutic Use Heart Failure Etiology Descriptive Statistics Data Analysis Software Perioperative Care Postoperative Complications Pericardial Effusion Risk Factors Embolism Catheter Ablation Equipment and Supplies Shock, Cardiogenic Death Risk Factors Confidence Intervals Catheter Ablation Adverse Effects Cardiac Tamponade Equipment Failure Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Introduction: Intramyocardial needle ablation is a novel technique for treating refractory ventricular tachycardia (VT) and premature ventricular complexes (PVC). However, studies defining the effectiveness and safety of this procedure are limited. This meta‐analysis aims to evaluate the safety and effectiveness of needle ablation for VT and PVC refractory to standard ablation. Methods: Embase, Ovid (includes Medline), and ClinicalTrials.gov were searched from inception to December 31, 2024. Human studies on needle ablation for recurrent VT and PVC were included. Primary outcome was immediate effectiveness (no immediate post‐procedural inducible VT or PVC). Secondary outcomes were long‐term effectiveness (no clinical VT or PVC at 6 months) and safety (composite measure of peri‐ and post‐procedural complications). Results: A total of five studies including 180 patients (140 VT; 40 PVC) were analyzed. Mean ages ranged from 54 to 66 years. Among 129 patients with VT, immediate effectiveness was 75% (95% CI, 54–92; I2 80%), and cumulative freedom from clinical VT dropped to 43% at 6 months (95% CI, 35–52; I2 0%). Among 40 patients with PVC, immediate effectiveness was 82% (95% CI, 67–94; I2 0%), and long‐term effectiveness was 76% (95% CI, 61–90; I2 0%). Safety outcomes were reported in 19% of patients (95% CI, 13–27; I2 0%) and 10% of patients (95% CI 1, 23; I2 0%) in the VT and PVC arm, respectively. Death related to ablation was report in 7 patients (5.0%) only in the VT studies. Conclusion: Intramyocardial needle ablation is an emerging alternative approach for refractory VT and PVC ablation, showing cautious but promising results and safety profiles. Prospective studies and an international registry could provide valuable insights needed for optimal patient selection and protocol refinement. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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