Diagnostic performance of the rapid urease test versus histopathology for diagnosing Helicobacter pylori: A prospective study in Saudi Arabia.
Background: Helicobacter pylori (H. pylori) can be quickly identified using a rapid urease test (RUT)/campylobacter-like organism (CLO) test, although its accuracy is often not comparable to histopathology. Therefore, this study aimed to examine the utility of the CLO test in routine endoscopy proce...
| Publicado en: | Electronic Journal of General Medicine Vol. 22; no. 5; pp. 1 - 7 |
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| Formato: | research tables/charts Journal Article |
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Modestum Publications
Oct2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188093646&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188093646 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 25163507 LNCB jtl: Electronic Journal of General Medicine issn: 25163507 maglogo: N pubinfo: dt: Oct2025 vid: 22 iid: 5 pid: 52459 pub: Modestum Publications place: , <Blank> artinfo: ui: 188093646 188093646 188093646 10.29333/ejgm/16898 188093646 ppf: 1 ppct: 6 formats: tig: atl: Diagnostic performance of the rapid urease test versus histopathology for diagnosing Helicobacter pylori: A prospective study in Saudi Arabia. aug: au: Alsulaiman, Raed Mohammed affil: Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA sug: subj: Helicobacter Infections Diagnosis Diagnostic Tests, Routine Histological Techniques Urease Analysis Sensitivity and Specificity Human Saudi Arabia Male Female Adolescence Adult Middle Age Aged Prospective Studies Biopsy Staining and Labeling Descriptive Statistics Data Analysis Software Confidence Intervals ROC Curve Reliability Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background: Helicobacter pylori (H. pylori) can be quickly identified using a rapid urease test (RUT)/campylobacter-like organism (CLO) test, although its accuracy is often not comparable to histopathology. Therefore, this study aimed to examine the utility of the CLO test in routine endoscopy procedures. Methods: This prospective study enrolled 100 patients undergoing upper gastrointestinal endoscopy. Gastric biopsies were used for CLO and histopathological examination of tissue. The CLO test's sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated, with histopathology as the reference standard. Results: The CLO test demonstrated a sensitivity of 32.5%, a specificity of 70.0%, a PPV of 81.25%, and an NPV of 20.59%. The overall accuracy was 40%. In patients with recent proton pump inhibitor or antibiotic use, the sensitivity and specificity of the CLO test were 85.71% and 100%, respectively. Conclusion: The CLO test's moderate capability in diagnosing H. pylori was observed, primarily due to its high PPV; however, its sensitivity is limited. When the CLO test result is negative, it may not detect all infections. Therefore, histopathology or additional tests should be considered. Further research is needed to understand the impact of medication use on test accuracy. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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