Identifying Biomarkers of Neuroplasticity Associated with Exercise-Induced Cognitive Change in Older Adults with MCI.
Objectives: This exploratory study aimed to identify biomarkers of neuroplasticity that prevent cognitive decline. This study examined activity-dependent changes in the neurologic proteome that contributed to post-exercise improvements in processing speed in older adults with mild cognitive impairme...
| Publicado en: | Experimental Aging Research Vol. 51; no. 5; pp. 643 - 657 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Oct-Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188122245&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188122245 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0361073X 1HO jtl: Experimental Aging Research issn: 0361073X maglogo: N pubinfo: dt: Oct-Dec2025 vid: 51 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 188122245 183314045 188122245 188122245 10.1080/0361073X.2025.2470579 188122245 ppf: 643 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Identifying Biomarkers of Neuroplasticity Associated with Exercise-Induced Cognitive Change in Older Adults with MCI. aug: au: Savettiere, Adriana Louras, Peter Langdon, Sarah Fairchild, J. Kaci affil: Department of Psychology, Palo Alto University, Palo Alto, California, USA sug: subj: Neuronal Plasticity Physiology Proteomics Evaluation Biological Markers Blood Cognition Disorders In Old Age Severity of Illness Therapeutic Exercise In Old Age Processing Speed Evaluation Human Male Female Middle Age Aged Aged, 80 and Over Exploratory Research Cognition Disorders Prevention and Control Community Living Veterans Psychosocial Factors Self Report Clinical Assessment Tools High-Intensity Interval Training Blood Specimen Collection T-Tests Neuropsychological Tests Pearson's Correlation Coefficient Data Analysis Software Descriptive Statistics Funding Source Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Objectives: This exploratory study aimed to identify biomarkers of neuroplasticity that prevent cognitive decline. This study examined activity-dependent changes in the neurologic proteome that contributed to post-exercise improvements in processing speed in older adults with mild cognitive impairment (MCI). Methods: Participants included 20 older adult Veterans with MCI recruited through the VA Palo Alto Health Care System (VAPAHCS) who participated in moderate-high intensity water-based activity thrice weekly for six months. Plasma protein concentration was measured using the Olink Target 96 Neurology Assay. Processing speed measures included the Trail Making Test Trial A (TMT-A), the Stroop Color (SC) and Word (SW) trials, and the Symbol Digit Modalities Test (SDMT). Results: Preliminary analyses revealed two proteins of interest: neuropilin-2 (NRP2) and neuroblastoma suppressor of tumorigenicity 1 (NBL1). Primary analyses used mixed effects models to determine the impact of changes in neurologic-related proteins on changes in processing speed after exercise. Results indicated that decreased levels of NRP2 were associated with improved outcomes on the SDMT after exercise. In contrast, changes in NBL1 had no significant effect on the relationship between exercise and processing speed. Conclusion: These results support previous research linking NRP2 function to synaptic plasticity downscaling and present NRP2 as a potential target for cognitive intervention. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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