Diffusion tensor imaging and diffusion kurtosis imaging of the pancreas - feasibility, robustness and protocol comparison in a healthy population.
Purpose: This study aims to determine the feasibility, image quality, intra-subject repeatability and inter-reader variability of Diffusion tensor (DTI) and Diffusion kurtosis imaging (DKI) for pancreatic imaging using different protocols and report normative values in healthy individuals. Methods:...
| Publicado en: | Abdominal Radiology Vol. 50; no. 10; pp. 4563 - 4575 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188150372&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188150372 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Oct2025 vid: 50 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 188150372 184033367 10.1007/s00261-025-04889-w 188150372 ppf: 4563 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Diffusion tensor imaging and diffusion kurtosis imaging of the pancreas - feasibility, robustness and protocol comparison in a healthy population. aug: au: Bilreiro, Carlos Andrade, Luisa Henriques, Rafael Loução, Nuno Matos, Celso Shemesh, Noam affil: https://ror.org/03g001n57 Champalimaud Foundation, Lisbon, Portugal sug: ab: Purpose: This study aims to determine the feasibility, image quality, intra-subject repeatability and inter-reader variability of Diffusion tensor (DTI) and Diffusion kurtosis imaging (DKI) for pancreatic imaging using different protocols and report normative values in healthy individuals. Methods: Single-institution prospective study performed on healthy volunteers in a clinical 3T scanner, using two different protocols (6/16 diffusion directions). Acquisitions were repeated twice to assess intra-subject repeatability. To assess inter-reader variability, Mean diffusivity (MD), Axial diffusivity (AD), Radial diffusivity (RD), Apparent diffusion coefficient (ADC) and Mean kurtosis (MK) values were extracted from segmented pancreas by two radiologists. A Likert scale was used by both readers to assess subjective image quality. Results: Twelve healthy volunteers were recruited for each MRI protocol. The 6 diffusion directions protocol was shorter: 7 min vs. 14 min (corresponding to 4 min vs. 7.5 min for a DTI only reconstruction). No differences in image quality were found between protocols. Only MK maps showed implausible estimates, leading to the exclusion of median 16% and 17.7% pixels for the 6- and 16-direction protocols, respectively. Intra-subject repeatability was determined with negligible coefficients of repeatability for DTI; however, MK presented slightly higher values. Inter-reader agreement was excellent for all maps (ICC > 0.9). Conclusions: DTI and DKI of the pancreas are feasible in clinical settings, with excellent inter-observer agreement and good image quality. Intra-subject repeatability is excellent for DTI, but some variability was observed with DKI. A 6-directions protocol may be preferred due to faster acquisition without quantitatively compromising estimates. MK inaccuracies prompt further research for improving artifact correction. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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