Efficacy of modified technique for 1 cm core needle biopsy using a 2 cm cutting length with coaxial introducer needle.
Purpose: This study evaluated the efficacy of a modified core needle biopsy using a 2 cm stroke length to improve tissue yield for molecular analyses in cancer genomics medicine. Methods: In vitro biopsy weight evaluations were performed using agarose gels of varying hardness. Ex vivo biopsy weight...
| Publicado en: | Abdominal Radiology Vol. 50; no. 10; pp. 5011 - 5019 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188150384&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188150384 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Oct2025 vid: 50 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 188150384 184071618 10.1007/s00261-025-04904-0 188150384 ppf: 5011 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Efficacy of modified technique for 1 cm core needle biopsy using a 2 cm cutting length with coaxial introducer needle. aug: au: Satomura, Hiroki Kimura, Yasushi Nakamura, Masahisa Tomotake, Kosuke Yamamoto, Koki Tanaka, Kaishu Ono, Yusuke Higashihara, Hiroki Tomiyama, Noriyuki affil: https://ror.org/035t8zc32 Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, Osaka, Japan sug: ab: Purpose: This study evaluated the efficacy of a modified core needle biopsy using a 2 cm stroke length to improve tissue yield for molecular analyses in cancer genomics medicine. Methods: In vitro biopsy weight evaluations were performed using agarose gels of varying hardness. Ex vivo biopsy weight evaluations were conducted using chicken liver, gizzard, breast, and pork loin tissues. Furthermore, in vivo experiments were performed using murine subcutaneous tumor models. The modified method involved using a coaxial introducer needle to maintain a 1 cm notch length while employing a 2 cm stroke length to increase tissue yield. Biopsy performance parameters, including sample weight and DNA yield, were compared between the modified and conventional methods. The firing speed of the biopsy needles with 1 cm and 2 cm stroke lengths was also measured using a high-speed camera. Results: The modified technique significantly increased the sample volume across all agarose gel concentrations (9.5–13% increase, P < 0.05). Ex vivo tests revealed significantly higher tissue yields in most samples, except for chicken gizzards. In vivo, the modified method produced significantly larger tissue samples (4.6 mg vs. 2.9 mg, P < 0.001) and higher DNA yield (8.2 ng vs. 6.9 ng, P < 0.05). In addition, the biopsy needle's firing speed was 1.4–1.8 times faster with the 2 cm stroke length than 1 cm stroke. Conclusion: The modified biopsy technique using a 2 cm stroke length significantly improved tissue yield, enhancing the quality of biopsy samples for molecular analyses in precision medicine. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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