Late Gadolinium Enhancement on Cardiac MRI and the Prognosis of Patients With Pulmonary Hypertension: A Meta‐Analysis.
Purpose: Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (MRI) is indicative of myocardial fibrosis and has been proposed as a prognostic marker in patients with pulmonary hypertension (PH). However, the strength and consistency of this association remain uncertain. This meta...
| Publicado en: | Echocardiography Vol. 42; no. 9; pp. 1 - 14 |
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| Autores principales: | , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188159088&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188159088 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Sep2025 vid: 42 iid: 9 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 188159088 188159088 188159088 10.1111/echo.70278 188159088 ppf: 1 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Late Gadolinium Enhancement on Cardiac MRI and the Prognosis of Patients With Pulmonary Hypertension: A Meta‐Analysis. aug: au: Han, Wenjuan Ban, Qijun Zhai, Deyin Zhai, Yujie affil: Department of Cardiology, Laizhou People's Hospital, Yantai Shandong Province,, China sug: subj: Elements Heart Radiography Magnetic Resonance Imaging Hypertension, Pulmonary Prognosis Image Enhancement Human Systematic Review Meta Analysis PubMed Embase Descriptive Statistics Confidence Intervals Data Analysis Software Checklists ab: Purpose: Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (MRI) is indicative of myocardial fibrosis and has been proposed as a prognostic marker in patients with pulmonary hypertension (PH). However, the strength and consistency of this association remain uncertain. This meta‐analysis aims to evaluate the relationship between LGE and adverse clinical outcomes in patients with PH. Methods: PubMed, Embase, and Web of Science were systematically searched from the inception of each database through March 28, 2025, for longitudinal observational studies reporting on the prognostic value of LGE detected by cardiac MRI in PH. Risk ratios (RRs) and 95% confidence intervals (CIs) were pooled using a random‐effects model to account for between‐study heterogeneity. Results: Ten studies involving 733 patients were included. The presence of LGE on cardiac MRI was associated with a nonsignificant trend toward increased risk of adverse clinical outcomes (RR = 1.23, 95% CI: 0.99–1.54; p = 0.07; I2 = 40%). A similar result was observed in the sensitivity analysis restricted to high‐quality studies (RR = 1.15, 95% CI: 0.98–1.36; p = 0.10; I2 = 14%). Subgroup analyses showed consistent trends across all stratifications, with no significant differences (all p > 0.05). No evidence of publication bias was detected. Conclusion: LGE on cardiac MRI may be associated with adverse outcomes in patients with PH; however, the current evidence remains inconclusive. Further large‐scale, prospective studies are warranted to clarify its prognostic value. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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