Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men.
Background: The automated segmentation of computed tomography (CT) images has made their opportunistic use more feasible, yet, the association of muscle area and density from multiple anatomical regions with functional outcomes and mortality risk in older adults has not been fully explored. We aimed...
| Publicado en: | Journal of the American Geriatrics Society Vol. 73; no. 9; pp. 2717 - 2727 |
|---|---|
| Autores principales: | , , , , |
| Formato: | Artículo |
| Publicado: |
Wiley-Blackwell
Sep2025
|
| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=188235342&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 188235342 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00028614 20Q jtl: Journal of the American Geriatrics Society issn: 00028614 maglogo: Y pubinfo: dt: Sep2025 vid: 73 iid: 9 pid: 480 pub: Wiley-Blackwell artinfo: ui: 188235342 10.1111/jgs.19583 ppf: 2717 ppct: 10 formats: tig: atl: Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men. aug: au: Hetherington‐Rauth, Megan Mansfield, Tyler A. Lenchik, Leon Weaver, Ashley A. Cawthon, Peggy M. affil: California Pacific Medical Center Research Institute, San Francisco California,, USA Wake Forest University School of Medicine, Winston‐Salem North Carolina,, USA University of California, Department of Epidemiology and Biostatistics, San Francisco California,, USA su: Analysis of variance Old age Bone fractures -- Prognosis Mortality risk factors Risk assessment Pearson correlation (Statistics) Skeletal muscle Adipose tissues Research funding Secondary analysis Computed tomography Scientific observation Fisher exact test Questionnaires Functional status Descriptive statistics Chi-squared test Bone fractures Longitudinal method Muscle strength Lumbar vertebrae Thigh Osteoporosis Data analysis software Walking speed Survival analysis (Biometry) Exercise tests Sarcopenia Regression analysis Proportional hazards models Grip strength Muscle contraction sug: subj: Analysis of variance Old age Irradiation Apparatus Manufacturing Bone fractures -- Prognosis Mortality risk factors Risk assessment Pearson correlation (Statistics) Skeletal muscle Adipose tissues Research funding Secondary analysis Computed tomography Scientific observation Fisher exact test Questionnaires Functional status Descriptive statistics Chi-squared test Bone fractures Longitudinal method Muscle strength Lumbar vertebrae Thigh Osteoporosis Data analysis software Walking speed Survival analysis (Biometry) Exercise tests Sarcopenia Regression analysis Proportional hazards models Grip strength Muscle contraction keyword: computed tomography machine learning power strength computed tomography machine learning power strength ab: Background: The automated segmentation of computed tomography (CT) images has made their opportunistic use more feasible, yet, the association of muscle area and density from multiple anatomical regions with functional outcomes and mortality risk in older adults has not been fully explored. We aimed to determine if muscle area and density at the L1 and L3 vertebra and right and left proximal thigh were similarly related to functional outcomes and 10‐year mortality risk. Methods: Men from the Osteoporotic Fractures in Men (MrOS) study who had CT images, measures of grip strength, 6 m walking speed, and leg power (Nottingham Power Rig) at the baseline visit were included in the analyses (n = 3290, 73.7 ± 5.8 years). CT images were automatically segmented to derive muscle area and muscle density. Deaths were centrally adjudicated over a 10‐year follow‐up. Linear regression and proportional hazards were used to model relationships of CT muscle metrics with functional outcomes and mortality, respectively, while adjusting for covariates. Results: Muscle area and density were positively related to functional outcomes regardless of anatomical region, with the most variance explained in leg power (adjusted R2 = 0.40–0.46), followed by grip strength (adjusted R2 = 0.25–0.29) and walking speed (adjusted R2 = 0.18–0.20). A one‐unit SD increase in muscle area and density was associated with a 5%–13% and 8%–21% decrease in the risk of all‐cause mortality, respectively, with the strongest associations observed at the right and left thigh. Conclusion: Automated measures of CT muscle area and density are related to functional outcomes and risk of mortality in older men, regardless of CT anatomical region. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
|---|