Risky decision-making in dementia: Exploring neural correlates and related clinical symptoms.
Background: Appropriately balancing potential risks versus rewards is important for affective decision-making in everyday life. Impaired affective decision-making on risk-taking tasks has been reported in individuals with dementia, but the neural correlates of such deficits, and whether they relate...
| Publicado en: | Cognitive, Affective & Behavioral Neuroscience Vol. 25; no. 5; pp. 1575 - 1596 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188240156&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188240156 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307026 NA4 jtl: Cognitive, Affective & Behavioral Neuroscience issn: 15307026 maglogo: N pubinfo: dt: Oct2025 vid: 25 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 188240156 184376575 10.3758/s13415-025-01291-3 188240156 ppf: 1575 ppct: 21 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Risky decision-making in dementia: Exploring neural correlates and related clinical symptoms. aug: au: Day, Molly-Eve Foxe, David Wei, Grace Burrell, James Piguet, Olivier Kumfor, Fiona Wong, Stephanie affil: https://ror.org/01kpzv902 College of Education, Psychology and Social Work, Flinders University, 5042, Bedford Park, South Australia, Australia sug: ab: Background: Appropriately balancing potential risks versus rewards is important for affective decision-making in everyday life. Impaired affective decision-making on risk-taking tasks has been reported in individuals with dementia, but the neural correlates of such deficits, and whether they relate to neuropsychiatric symptoms, such as disinhibition and apathy, have not been directly examined. Methods: Forty-one behavioural-variant frontotemporal dementia (bvFTD), 28 Alzheimer's disease (AD) patients and 42 healthy controls completed the Balloon Analogue Risk Task (BART), which assessed their ability to weigh risks versus rewards to maximise monetary earnings. Informant-reported measures of disinhibition and apathy were completed. All participants underwent structural magnetic resonance imaging brain scans. Results: While bvFTD and AD patients showed some impairments on the BART relative to controls, a high degree of variability was observed within patient groups. Poorer BART performance was associated with bilateral medial prefrontal and orbitofrontal cortex atrophy. A hierarchical cluster analysis revealed four groups of patients, with distinct patterns of BART performance, varying levels of disinhibition and apathy, and divergent patterns of brain atrophy. The group that showed the worst performance on the BART (i.e., collected the least money and popped the most balloons) showed the greatest disinhibition and orbitofrontal cortex atrophy. Conclusions: Our findings highlight the heterogeneous nature of affective decision-making deficits in dementia and uncover important links between BART performance, symptoms of disinhibition and apathy, and orbitofrontal cortex atrophy. Greater understanding of these symptom profiles and underlying neurocognitive mechanisms may help to inform potential management strategies for impaired affective decision-making in dementia. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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