Frequency of Autoimmunity in Children With Autism Spectrum Disorders and Their Parents: A Cross-sectional Study.
Background: Autism spectrum disorder (ASD) is a neurobiological condition shaped by genetic, epigenetic, and environmental elements impacting the growing brain and marked by impaired social and emotional interaction, difficulties in learning, anxiety, epilepsy, language impairments, restrictive acti...
| Publicado en: | Journal of Pediatrics Review Vol. 13; no. 3; pp. 257 - 263 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mazandaran University of Medical Sciences
Jul2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188274707&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188274707 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23224398 HC3Y jtl: Journal of Pediatrics Review issn: 23224398 maglogo: N pubinfo: dt: Jul2025 vid: 13 iid: 3 pid: 45683 pub: Mazandaran University of Medical Sciences artinfo: ui: 188274707 188274707 188274707 10.32598/jpr.13.3.985.1 188274707 ppf: 257 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Frequency of Autoimmunity in Children With Autism Spectrum Disorders and Their Parents: A Cross-sectional Study. aug: au: Heravi, Nasser Hosseini, Seyed Ahmad Ghelichi-Ghojogh, Mousa Aghapour, Seyed Ali affil: Neonatal & Children's Health Research Center, School of Health, Golestan University of Medical Sciences, Gorgan, Iran sug: subj: Autoimmune Diseases Epidemiology Autism Spectrum Disorder Immunology Immunity In Infancy and Childhood Children with Disabilities Psychosocial Factors Parents of Children with Disabilities Psychosocial Factors Iran Human Funding Source Female Male Infant Child, Preschool Child Adolescence Parent-Child Relations Cross Sectional Studies Autism Spectrum Disorder Epidemiology Fluorescent Antibody Technique C-Reactive Protein Blood Cell Count Descriptive Statistics Comparative Studies Biological Markers DSM Enzyme-Linked Immunosorbent Assay Blood Specimen Collection Data Analysis Software Biological Assay Staining and Labeling Chi Square Test Fisher's Exact Test Mann-Whitney U Test Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Female Male ab: Background: Autism spectrum disorder (ASD) is a neurobiological condition shaped by genetic, epigenetic, and environmental elements impacting the growing brain and marked by impaired social and emotional interaction, difficulties in learning, anxiety, epilepsy, language impairments, restrictive actions, and the existence of limited interests and repetitive actions. Objectives: This study aimed to determine the frequency of autoimmunity in children with ASDs and their parents in Gorgan in 2021. Methods: The study with a cross-sectional design was carried out in Gorgan City, located in the northeast of Iran. Subjects included autistic patients covered by the Welfare Organization of Golestan Province. All children underwent an anti-nuclear antibody test, C-reactive protein (CRP), and complete blood count. Parents of children with seropositive antibodies were tested for antinuclear antibodies, CRP, and complete blood count. Data were analyzed using analytical-descriptive statistics. Results: A total of 43 boys (76.8%) and 13 girls (23.2%) with ASD were included in the study. The mean age of children was 10.04±3.99 years, with a range of 1-18 years. Based on the findings of the anti-nuclear antibody test, patients were divided into two groups: Those with autoimmune disease (13 patients; 23.21%) and those without autoimmunity (43 patients; 76.79%). CRP was positive in 53.8% of the autoimmune patients and 18.6% of the non-autoimmune patients (P=0.013). Conclusions: There is an association between ASD and autoimmune disease. However, more research is needed with a larger population of patients to determine if these antibodies play a role in inducing autoimmunity in a subset of autistic children. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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