Focal Therapy for Localized Prostate Cancer: A Case Series with Cost Analysis.
Simple Summary: Prostate cancer treatment has shifted dramatically over the last decade. In this manuscript, a case series of three different focal therapy modalities (high-intensity focused ultrasound, cryoablation, and irreversible electroporation of the prostate) to treat prostate cancer is repor...
| Publicado en: | Current Oncology Vol. 32; no. 9; pp. 476 - 490 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
MDPI
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188283500&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188283500 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11980052 5EKK jtl: Current Oncology issn: 11980052 maglogo: N pubinfo: dt: Sep2025 vid: 32 iid: 9 pid: 97109 pub: MDPI artinfo: ui: 188283500 10.3390/curroncol32090476 188283500 ppf: 476 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Focal Therapy for Localized Prostate Cancer: A Case Series with Cost Analysis. aug: au: Sandberg, Maxwell Thole, David Nowatzke, Jackson Underwood, Gavin Ye, Emily Rais-Bahrami, Soroush Davis, Ronald Rodriguez, Alejandro affil: Department of Urology, Wake Forest University School of Medicine, Winston Salem, NC 27101, USA sug: ab: Simple Summary: Prostate cancer treatment has shifted dramatically over the last decade. In this manuscript, a case series of three different focal therapy modalities (high-intensity focused ultrasound, cryoablation, and irreversible electroporation of the prostate) to treat prostate cancer is reported. The analysis compares functional and oncologic controls. Focal therapy provides adequate functional outcomes with oncologic control like established whole-gland therapies. Additionally, the cost by treatment modality is compared, often disregarded when considering focal therapy. Lastly, a brief narrative review of the literature was conducted to contextualize our findings. Focal therapy for prostate cancer (PCa) provides approaches to treat PCa patients in a less invasive manner than traditional whole-gland surgical or radiation modalities. This manuscript provides a case series of high-intensity focused ultrasound (HIFU), cryoablation, and irreversible electroporation (IRE) for PCa at a single institution and cost analysis with a review of the literature. All patients who underwent HIFU, cryoablation, or IRE for localized PCa were retrospectively reviewed, excluding patients who received whole-gland therapy. Functional outcomes were erectile dysfunction and lower urinary tract symptoms. Cost data were collected. A total of 45 patients were included in the study with focal therapy ranging from 2023 to 2025 (4 HIFU, 20 cryoablation, 21 IRE). A total of 30 patients had focally treated lesions, and 15 patients had hemi-gland treatment. The mean preoperative PSA was 7.7 ng/mL. On the paired sample t-test, there was no significant difference between pre-focal and post-focal therapy PSA. Three patients experienced biochemical recurrence requiring prostate biopsy after focal treatment. Mean cost was USD 3804.50 and not significantly different by focal treatment. No metastatic events occurred nor deaths at a median follow-up of 6 months. Patients in this series had largely unaltered functional outcomes. Cost analysis in contemporary publications is lacking. Although follow-up was short, cancer control was adequate. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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