| Sumario: | Simple Summary: Parents of children with cancer often face intense stress but may also experience positive psychological changes, known as post-traumatic growth. While such growth has been studied in cancer patients, research on parents remains limited, particularly in Latvia. We followed 58 parents of children treated at the Children's Clinical University Hospital in Riga, using both questionnaires and interviews. Our study found two groups of parents: those who showed little growth and those who reported moderate to high levels of growth. It was reflected in changed life values, reduced focus on minor stressors, and greater acceptance of life. Growth was not directly related to post-traumatic stress symptoms, but it was positively associated with engagement coping and personality traits such as extraversion and openness. Our findings highlight the importance of adaptive coping, reflection, and social support. These insights can guide future research, inform psychosocial interventions, and support policy aimed at improving parental well-being. Background: This study explores post-traumatic growth (PTG) among parents of childhood cancer survivors (CCSs), a group often underrepresented in research. Method: A convergent parallel mixed-methods design integrating Bayesian Multilevel Latent Class Analysis and Thematic Analysis was utilized in a longitudinal study involving 58 caregivers (50 mothers, 8 fathers) from the Children's Clinical University Hospital in Riga. Quantitative data were collected at diagnosis using the Psychosocial Assessment Tool (PAT) and Big Five Inventory-10 (BFI-10). Follow-up assessments post-treatment included the Responses to Stress Questionnaire (RSQ), Impact of Event Scale-Revised (IES-R), and the Post-traumatic Growth Inventory (PTGI). Qualitative data were collected through structured interviews. Results: A 2-class model distinguished parents with low PTG from those with moderate to high PTG. Change in values, detachment from trivial stressors, and acceptance of life emerged as key indicators of growth. PTG was not significantly correlated with overall post-traumatic stress symptoms, but engagement coping strategies showed a positive association with PTG and personality traits like extraversion and openness. Conclusions: The mixed methods approach revealed sample-specific PTG elements not reflected in standardized tools. Initial perceptions of the cancer diagnosis shaped psychological outcomes, with PTG facilitated by adaptive coping, self-reflection, support, emotional disclosure, and psychological struggle. This study offers the first insights into PTG among Latvian parents of CCSs, a previously unexplored area.
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