Limonin: Advances in extraction, synthesis, pharmacological mechanisms, and structural optimization for therapeutic potential.
Limonin, a highly oxygenated nor-triterpenoid phytochemical abundant in Citrus plants, has attracted considerable attention because of its diverse pharmacological properties. Its significant anti-inflammatory, antioxidant, anticancer, antifungal, and antiviral activities have been demonstrated in re...
| Publicado en: | Fitoterapia Vol. 186 |
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| Autores principales: | , , , , , , |
| Formato: | review Journal Article |
| Publicado: |
Elsevier B.V.
Oct2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188290807&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188290807 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0367326X JF4 jtl: Fitoterapia issn: 0367326X maglogo: N pubinfo: dt: Oct2025 vid: 186 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 188290807 188290807 188290807 10.1016/j.fitote.2025.106861 188290807 ppct: 1 formats: tig: atl: Limonin: Advances in extraction, synthesis, pharmacological mechanisms, and structural optimization for therapeutic potential. aug: au: Meng, Xianghui Xi, Zhichao Chen, Xinwei Green, Donovan Zhou, Yunhao Xian, Yao Zhang, Hongmei affil: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China sug: subj: Citrus Plant Extracts Phytochemicals Pharmacodynamics Phytochemicals Analysis Chemical Fractionation Molecular Structure Phytochemicals Therapeutic Use Antiinflammatory Agents Antioxidants Antineoplastic Agents ab: Limonin, a highly oxygenated nor-triterpenoid phytochemical abundant in Citrus plants, has attracted considerable attention because of its diverse pharmacological properties. Its significant anti-inflammatory, antioxidant, anticancer, antifungal, and antiviral activities have been demonstrated in recent studies and are associated with the modulation of multiple signaling pathways, highlighting its potential as a valuable lead compound for therapeutic development. However, poor solubility and limited bioavailability constrain its practical application, prompting interest in chemical synthesis and structural modification strategies to enhance therapeutic potential. This review systematically summarizes recent advances in the extraction, synthesis, pharmacological mechanisms, and structural optimization of limonin, including comparisons of extraction processes and analyses of structure–activity relationships. It further aims to encourage additional research on limonin and its derivatives and to support their clinical translation. [Display omitted] • Advances in extraction, synthesis, pharmacology, and structural modification of limonin are systematically reviewed. • Emerging extraction and synthetic strategies enhance the recovery and sustainability of limonin. • Limonin exhibits anti-inflammatory, antioxidant, and anticancer effects through multi-target mechanisms. • Structural modifications produce derivatives with improved pharmacological activity and bioavailability. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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