Preliminary Outcomes from PrEP Well: A Community-led, Multicomponent HIV Prevention Strategy Implemented in a Transgender Community Health Center.
Transgender and nonbinary (TGNB) individuals are disproportionately impacted by HIV, particularly those who identify as racial/ethnic minorities and those who are socioeconomically disadvantaged. Pre-exposure prophylaxis (PrEP) is a highly effective medication to prevent HIV infection, but many TGNB...
| Published in: | Journal of Community Health Vol. 50; no. 5; pp. 842 - 860 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
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Springer Nature
Oct2025
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=188314381&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 188314381 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00945145 JCH jtl: Journal of Community Health issn: 00945145 maglogo: N pubinfo: dt: Oct2025 vid: 50 iid: 5 pid: 237 pub: Springer Nature artinfo: ui: 188314381 10.1007/s10900-025-01468-4 ppf: 842 ppct: 18 formats: fmt: – @attributes: type: T – @attributes: type: P size: 1.9MB tig: atl: Preliminary Outcomes from PrEP Well: A Community-led, Multicomponent HIV Prevention Strategy Implemented in a Transgender Community Health Center. aug: au: Storholm, Erik D. Nacht, Carrie L. Opalo, Chloe Flynn, Risa Murtaugh, Kimberly Ling Marroquin, Mariana Baumgardner, Mika Dopp, Alex R. affil: https://ror.org/0264fdx42 School of Public Health, San Diego State University, 5500 Campanile Dr, 92182, San Diego, CA, USA https://ror.org/00f2z7n96 RAND, Santa Monica, CA, USA https://ror.org/046rm7j60 Center for HIV Identification, Prevention, and Treatment Services (CHIPTS), University of California, Los Angeles, CA, USA https://ror.org/0264fdx42 Health Promotion & Behavioral Science, San Diego State University School of Public Health, 5500 Campanile Drive, Hepner Hall 114E, 92182 - 4162, San Diego, CA, USA https://ror.org/0168r3w48 Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA Trans Wellness Center, Los Angeles, CA, USA https://ror.org/05fkp1h83 Los Angeles LGBT Center, Los Angeles, CA, USA https://ror.org/046rm7j60 Department of Public Policy, Luskin School of Public Affairs, University of California, Los Angeles, Los Angeles, CA, USA su: Community health services Patient compliance Health services accessibility World Wide Web Cultural awareness Human services programs Qualitative research Interviewing Content analysis Affinity groups Nonbinary people Medical screening Drugs Community-based social services Patients' attitudes Sexual health Diagnosis of HIV infections HIV prevention Patient education Medical prescriptions T-test (Statistics) Research funding Gender affirming care Scientific observation Teaching aids Treatment effectiveness Descriptive statistics Chi-squared test Pre-exposure prophylaxis Antiviral agents Longitudinal method Surveys Combined modality therapy Attitudes of medical personnel Statistics Medical appointments Urinalysis Research methodology Electronic health records Application software Data analysis software Exit interviewing Human comfort Patient aftercare Medical referrals sug: subj: Community health services Patient compliance Health services accessibility World Wide Web Cultural awareness Human services programs Qualitative research Interviewing Content analysis Affinity groups Nonbinary people Medical screening Drugs Community-based social services Patients' attitudes Sexual health Pharmaceutical and medicine manufacturing Software Publishers Custom Computer Programming Services Software publishers (except video game publishers) All Other Outpatient Care Centers Community health centres Other Individual and Family Services Residential Mental Health and Substance Abuse Facilities Other local, municipal and regional public administration Pharmaceuticals and pharmacy supplies merchant wholesalers Drugs and Druggists' Sundries Merchant Wholesalers Home Health Care Services All Other Miscellaneous Ambulatory Health Care Services Internet Publishing and Broadcasting and Web Search Portals Diagnosis of HIV infections HIV prevention Patient education Medical prescriptions T-test (Statistics) Research funding Gender affirming care Scientific observation Teaching aids Treatment effectiveness Descriptive statistics Chi-squared test Pre-exposure prophylaxis Antiviral agents Longitudinal method Surveys Combined modality therapy Attitudes of medical personnel Statistics Medical appointments Urinalysis Research methodology Electronic health records Application software Data analysis software Exit interviewing Human comfort Patient aftercare Medical referrals keyword: Health Equity HIV Prevention Implementation Strategies Medical and Health Sciences Public Health and Health Services PrEP Transgender Community Health Equity HIV Prevention Implementation Strategies Medical and Health Sciences Public Health and Health Services PrEP Transgender Community ab: Transgender and nonbinary (TGNB) individuals are disproportionately impacted by HIV, particularly those who identify as racial/ethnic minorities and those who are socioeconomically disadvantaged. Pre-exposure prophylaxis (PrEP) is a highly effective medication to prevent HIV infection, but many TGNB individuals encounter barriers to PrEP uptake and adherence that limit fully realized preventive benefits. We developed PrEP Well, a multicomponent community-led program, to scale and sustain comprehensive PrEP services from a TGNB-led community organization that provides gender-affirming healthcare and social services. We used implementation science frameworks to evaluate initial program outcomes and contextual influences on program implementation. Preliminary data from August 2022 through January 2024 showed promising implementation and effectiveness outcomes. During that time, 113 primarily low-resourced TGNB clients were educated about PrEP and received an HIV test, of whom 60 (53%) attended a visit with a provider and received a PrEP prescription. At 30-day follow-up, urinalysis confirmed uptake of PrEP among 50 (83%) of the clients prescribed PrEP. At 90-day follow-up, 43 (72%) demonstrated continued use of PrEP and 40 (67%) showed protective levels of PrEP adherence. Qualitative interviews and surveys indicated that clients, staff, and leadership viewed the PrEP Well program as highly acceptable, feasible, and sustainable (including willingness to address persistent implementation barriers). Referral patterns and rates of PrEP uptake suggested increasing integration of PrEP Well into the TGNB community center over time. The PrEP Well program demonstrates the potential for TGNB communities to address HIV inequities by integrating community-led HIV prevention services with gender-affirming healthcare in TGNB-specific health centers. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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