Abscisic Acid as a Marker of Metabolic Imbalance: Serum Levels from Diabetic and Smoking Subjects.
Background: Abscisic acid (ABA), a phytohormone widely distributed in nature, has recently emerged as an endogenous regulator of glucose homeostasis in humans. Specifically, scientific studies have demonstrated that exogenous ABA supplementation improves glycemic control and reduces insulin requirem...
| Publicado en: | Diabetology Vol. 6; no. 9; pp. 93 - 105 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
MDPI
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188350508&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188350508 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26734540 N1A2 jtl: Diabetology issn: 26734540 maglogo: N pubinfo: dt: Sep2025 vid: 6 iid: 9 pid: 97109 pub: MDPI artinfo: ui: 188350508 188350508 188350508 10.3390/diabetology6090093 188350508 ppf: 93 ppct: 12 formats: tig: atl: Abscisic Acid as a Marker of Metabolic Imbalance: Serum Levels from Diabetic and Smoking Subjects. aug: au: Abate, Federico Schiano, Elisabetta Guerra, Fabrizia Piccinocchi, Gaetano Tenore, Gian Carlo Novellino, Ettore affil: Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy sug: subj: Ascorbic Acid Blood Biological Markers Blood Metabolic Diseases Blood Smoking Complications Diabetes Mellitus Complications Inflammation Drug Therapy Human Male Female Middle Age Aged Cross Sectional Studies Blood Glucose Metabolism Dietary Supplementation Glycemic Control Drug Effects Insulin Sensitivity Immune System Drug Effects Correlational Studies Nonexperimental Studies Anthropometry Blood Glucose Monitoring Structured Questionnaires Cholesterol Drug Effects Lipoproteins, LDL Drug Effects Lipoproteins, HDL Drug Effects Triglycerides Drug Effects Aspartate Aminotransferase Drug Effects Alanine Aminotransferase Drug Effects Uric Acid Drug Effects Sex Factors Glycated Hemoglobin Drug Effects Enzyme-Linked Immunosorbent Assay Mass Spectrometry Two-Way Analysis of Variance Post Hoc Analysis One-Way Analysis of Variance Hematologic Tests Pearson's Correlation Coefficient Analysis of Covariance Linear Regression Disease Duration Descriptive Statistics Data Analysis Software Liver Drug Effects Age Factors Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background: Abscisic acid (ABA), a phytohormone widely distributed in nature, has recently emerged as an endogenous regulator of glucose homeostasis in humans. Specifically, scientific studies have demonstrated that exogenous ABA supplementation improves glycemic control and reduces insulin requirements, with significant advantages in prediabetic subjects. Beyond its metabolic role, growing evidence suggests that ABA is also involved in immune responses, including those associated with pulmonary diseases. Despite these promising results, the evaluation of plasma ABA levels remains largely unexplored in clinical practice. Methods: This study aimed to evaluate whether plasma ABA concentrations differ among healthy individuals, patients with type 2 diabetes, and smokers, in order to clarify the role of ABA as a potential biomarker of both metabolic imbalance and smoking-related inflammatory stress. Results: Our findings show that ABA levels were significantly higher in healthy subjects (10.9 ± 3.8 ng/mL) compared to diabetic patients (6.8 ± 4.2 ng/mL, p < 0.01 vs. healthy subjects), with the lowest levels observed in smokers (3.5 ± 2.5 ng/mL, p < 0.0001 vs. healthy subjects and p < 0.0001 vs. diabetic patients). Moreover, a significant correlation was observed between ABA plasma concentration and number of cigarettes smoked (R2 = −0.6776, p = 0.0001). Conclusions: Overall, these results highlight the relevance of measuring ABA plasma levels in both metabolic and inflammatory conditions, confirming its role as a biomarker for identifying individuals who can benefit from exogenous supplementation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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