Risk factors for predicting acute kidney injury in children with septic shock: a retrospective cohort study.
Background: Acute kidney injury (AKI) is a prevalent and severe complication of septic shock in children, yet data on its risk factors remain scarce. This study aims to identify key predictors for AKI in this population and develop a clinical model for early risk assessment. Methods: We conducted a...
| Publicado en: | Pediatric Nephrology Vol. 40; no. 11; pp. 3563 - 3576 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188353549&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188353549 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Nov2025 vid: 40 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 188353549 185857108 188353549 188353549 10.1007/s00467-025-06834-x 188353549 ppf: 3563 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Risk factors for predicting acute kidney injury in children with septic shock: a retrospective cohort study. aug: au: Fang, Yu Zheng, Weihong Chen, Kepei Gao, Qiqi Jin, Wenwen Hu, Wei Chen, Yu Lin, Zhenlang Pan, Guoquan Lin, Wei affil: https://ror.org/0156rhd17 Department of Pediatrics, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China sug: subj: Kidney Failure, Acute Risk Factors Shock, Septic Complications Risk Assessment Early Diagnosis Human Prospective Studies Prediction Models Tertiary Health Care China Descriptive Statistics Proteinuria Calcitonin Blood Urea Nitrogen Prothrombin Time Antibiotics Therapeutic Use Confidence Intervals ROC Curve Sensitivity and Specificity Calibration Infant, Newborn Infant Child, Preschool Child Adolescence Retrospective Design Data Analysis Software Multiple Logistic Regression Multivariate Analysis T-Tests Mann-Whitney U Test Correlational Studies Funding Source Infant, Newborn: birth-1 month Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years ab: Background: Acute kidney injury (AKI) is a prevalent and severe complication of septic shock in children, yet data on its risk factors remain scarce. This study aims to identify key predictors for AKI in this population and develop a clinical model for early risk assessment. Methods: We conducted a retrospective analysis of clinical data from 180 children diagnosed with septic shock at a large tertiary hospital in China over 10 years. Multivariate analysis was performed to identify independent risk factors for AKI. Based on the results of the multivariate analysis, a clinical predictive nomogram for assessing the risk of sepsis-associated AKI (SA-AKI) in children with septic shock was established and validated using the "rms" package in R 4.3.0 software. Results: The incidence of AKI in children with septic shock was 44.4%, with significant predictors identified as greater height (95% CI 1.01–1.04), positive random proteinuria (95% CI 1.17–13.09), elevated procalcitonin levels (95% CI 1.00–1.04), base excess (95% CI 0.85–0.99), increased blood urea nitrogen levels (95% CI 1.03–1.22), and prolonged prothrombin time by ≥ 3 s (95% CI 1.13–11.43). Early use of antibiotics (95% CI 0.03–0.77) demonstrated a protective effect. The developed clinical predictive nomogram's ROC curve AUC was 0.895 (95% CI 0.836–0.955), with a sensitivity of 77.1% and specificity of 88.9%. It outperformed individual variables in predicting SA-AKI, and demonstrated good calibration and clinical utility as shown by the calibration and DCA curve. Internal validation by the bootstrap resampling method (1000 times) confirmed the model's accuracy with an AUC of 0.895 (95% CI 0.893–0.896). Conclusions: Recognizing these risk factors facilitates timely interventions for pediatric patients with septic shock. The nomogram serves as a valuable tool for clinicians, improving the management of AKI and potentially enhancing patient outcomes. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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