Probiotics and inflammatory bowel disease: an umbrella meta-analysis of relapse, recurrence, and remission outcomes.
Background: Inflammatory Bowel Diseases (IBD) encompass chronic inflammatory conditions such as ulcerative colitis and Crohn's disease. This umbrella meta-analysis investigates the efficacy of probiotic supplementation in reducing relapse, recurrence, and maintaining remission in IBD patients. Metho...
| Publicado en: | Nutrition & Metabolism Vol. 22; no. 1; pp. 1 - 16 |
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| Autores principales: | , , , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
BioMed Central
9/30/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188356923&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188356923 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 9/30/2025 vid: 22 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 188356923 188356923 188356923 10.1186/s12986-025-01002-2 188356923 ppf: 1 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Probiotics and inflammatory bowel disease: an umbrella meta-analysis of relapse, recurrence, and remission outcomes. aug: au: Liu, Wei Zhang, Shengbo Dong, Changzheng Lv, Xia Zheng, Ximin Zhao, Wei Jamali, Mehrdad Abedi, Ranasadat Saedisomeolia, Ahmad affil: https://ror.org/05jb9pq57 Department of Gastrointestinal Surgery, People's Hospital Affiliated to Shandong First Medical University, No. 001, Xuehu Street, Changshao North Road, Laiwu District, 271100, Jinan, China sug: subj: Inflammatory Bowel Diseases Drug Therapy Probiotics Therapeutic Use Dietary Supplementation Recurrence Disease Remission Treatment Outcomes Evaluation Drug Efficacy Evaluation Human Systematic Review Meta Analysis PubMed Colitis, Ulcerative Crohn Disease Treatment Effect Heterogeneity Embase Maximum Likelihood Effect Size Correlation Coefficient Quality Assessment Relative Risk Confidence Intervals Publication Bias Data Analysis Software Descriptive Statistics Funding Source ab: Background: Inflammatory Bowel Diseases (IBD) encompass chronic inflammatory conditions such as ulcerative colitis and Crohn's disease. This umbrella meta-analysis investigates the efficacy of probiotic supplementation in reducing relapse, recurrence, and maintaining remission in IBD patients. Methods: We systematically searched PubMed, Scopus, and Web of Science up to November 2024 for meta-analyses evaluating probiotics in IBD. A random-effects model calculated pooled effect sizes. The methodological quality of included reviews was assessed using AMSTAR 2. Publication bias was evaluated through funnel plots, Egger's and Begg's tests, and corrected by trim-and-fill when appropriate. Results: Twenty meta-analyses including 46 datasets were analyzed. Probiotics significantly reduced relapse risk compared to placebo (RR = 0.55; 95% CI, 0.22–0.88), but showed no significant effect compared to mesalazine. No consistent benefit was found for remission or recurrence; however, recurrence risk was reduced after correction for publication bias (RR:0.74;95%CI:0.51–0.97, P < 0.05). Subgroup analyses suggested greater benefit with lower probiotic doses (≤ 10¹⁰ Colony-Forming Units/day) and longer supplementation durations (≥ 8 weeks) regarding to relapse rate, although strain-specific effects could not be clarified. Conclusion: Probiotic supplementation appears effective in reducing relapse compared to placebo, but shows no advantage over mesalazine and demonstrates benefit for recurrence only after adjusting for publication bias. These findings highlight a potential role for probiotics in IBD management, but interpretation should be cautious given the high heterogeneity and substantial overlap among included meta-analyses. Further high-quality, non-overlapping meta-analyses and randomized controlled trials are needed to determine the most effective probiotic regimens. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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