Frailty assessed by a wrist-worn device can predict hospitalisation and mortality in middle-aged and older adults: a UK Biobank study.
Background Digital gait biomarkers (DGBs) from wrist-worn devices may offer a simple, convenient method for assessing frailty; however, their clinical validity has not been sufficiently verified. This study aimed to determine whether frailty assessed using DGBs is not inferior to the Fried frailty p...
| Publicado en: | Age & Ageing Vol. 54; no. 8; pp. 1 - 11 |
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| Autores principales: | , , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
Aug2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=188373789&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 188373789 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Aug2025 vid: 54 iid: 8 pid: 622 pub: Oxford University Press / USA artinfo: ui: 188373789 10.1093/ageing/afaf210 ppf: 1 ppct: 10 formats: tig: atl: Frailty assessed by a wrist-worn device can predict hospitalisation and mortality in middle-aged and older adults: a UK Biobank study. aug: au: Osuka, Yosuke Chan, Lloyd L Y Brodie, Matthew Okubo, Yoshiro Lord, Stephen R affil: Department of Frailty Research, Center for Geriatrics and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan Falls, Balance and Injury Research Center, Neuroscience Research Australia, Sydney, New South Wales, Australia School of Health Sciences, University of New South Wales, Sydney, New South Wales, Australia Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia School of Population Health, University of New South Wales, Sydney, New South Wales, Australia keyword: aged biological markers digital biomarkers frailty frailty assessment fried foods middle-aged middle-aged adult mortality older adult older people phenotype prediction uk biobank wrist aged biological markers digital biomarkers frailty frailty assessment fried foods middle-aged middle-aged adult mortality older adult older people phenotype prediction uk biobank wrist ab: Background Digital gait biomarkers (DGBs) from wrist-worn devices may offer a simple, convenient method for assessing frailty; however, their clinical validity has not been sufficiently verified. This study aimed to determine whether frailty assessed using DGBs is not inferior to the Fried frailty phenotype for predicting hospitalisation and mortality. Methods This longitudinal study included 10 156 adults (aged 43–81 years) with complete Fried frailty phenotype and DGB data from the UK Biobank. DGBs were extracted using validated algorithms on raw data from wrist-worn accelerometers over 7 days. DGB frailty was derived from DGBs and the Fried frailty phenotype. Results First hospitalisations and deaths were followed for 4.4 ± 2.7 and 7.2 ± 0.7 years, respectively. In these periods, 6148 (60.5%) were hospitalised (44 277 person-years follow-up) and 270 (2.7%) died (73 312 person-years follow-up). Cox proportional hazards models, adjusting for confounders, showed that both Fried and DGB frailties were predictive of hospitalisation (hazard ratios and 95% confidence intervals [CIs]: 1.29 [1.13–1.47] versus 1.33 [1.17–1.52]) and mortality (1.63 [1.01–2.62] versus 1.77 [1.14–2.74]). The mean differences (DGB frailty – Fried frailty) and 95% CIs in Harrell's C-index for hospitalisation and mortality were 0.000 [−0.002 to 0.001] and 0.002 [−0.004 to 0.009], respectively, with the lower limit of the 95% CIs exceeding the prespecified noninferiority margin (−0.1). Conclusion DGB-derived frailty predicted hospitalisation and mortality and was not inferior to the Fried frailty phenotype. These findings support the clinical validity and potential utility of wearable devices in the assessment of frailty in clinical practice. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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