Blood pressure and all-cause mortality in dementia: a nationwide cohort study.
Background Comorbidities are crucial in managing hypertension, but studies on individuals with dementia are lack. This study investigated the association between blood pressure (BP) and all-cause mortality in dementia. Methods We analysed 146 832 individuals newly diagnosed with dementia (2008–2016)...
| Publicado en: | Age & Ageing Vol. 54; no. 8; pp. 1 - 12 |
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| Autores principales: | , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Aug2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=188373817&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 188373817 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Aug2025 vid: 54 iid: 8 pid: 622 pub: Oxford University Press / USA artinfo: ui: 188373817 10.1093/ageing/afaf239 ppf: 1 ppct: 11 formats: tig: atl: Blood pressure and all-cause mortality in dementia: a nationwide cohort study. aug: au: Yoo, Jung Eun Han, Kyungdo Jung, Jin-Hyung Park, Kye-Yeung Lee, Chung-Woo Shin, Dong Wook Nam, Ga Eun affil: Department of Family Medicine, Healthcare System Gangnam Center Seoul National University Hospital, 152 Teheran-ro, Gangnam-gu, Seoul 06236, Republic of Korea Department of Family Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea Department of Statistics and Actuarial Science, Soongsil University, 369 Sangdo-ro, Dongjak-gu, Seoul 06978, Republic of Korea Health Insurance Review and Assessment Service, 60 Hyeoksin-ro, Wonju-si, Gangwon-do 26464, Republic of Korea Department of Family Medicine, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea Department of Family Medicine, Veterans Health Service Medical Center, 53 Jinhwangdo-ro 61-gil, Gangdong-gu, Seoul 05368, Republic of Korea Department of Family Medicine/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul 06351, Republic of Korea Department of Family Medicine, Korea University Guro Hospital, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul 08308, Republic of Korea keyword: all-cause mortality antihypertensive agents blood pressure dementia hypertension hypotension mortality older adult older people all-cause mortality antihypertensive agents blood pressure dementia hypertension hypotension mortality older adult older people ab: Background Comorbidities are crucial in managing hypertension, but studies on individuals with dementia are lack. This study investigated the association between blood pressure (BP) and all-cause mortality in dementia. Methods We analysed 146 832 individuals newly diagnosed with dementia (2008–2016) who underwent national health screening within 4 years after their dementia diagnosis. Dementia was defined using prescriptions for anti-dementia medications and relevant ICD-10 codes. Participants were categorised by systolic BP (SBP) and diastolic BP (DBP). All-cause mortality was assessed using multivariable Cox proportional hazards regression. Results The cohort's mean age was 75.1 years, with 35.5% men. Over a mean follow-up of 3.7 years, there were 52,118 deaths (35.5%). A reverse J-shaped association was observed between SBP and mortality, with nadir at SBP 138 mmHg on cubic spline curve (P for trend <.001). Compared to SBP 120–129 mmHg, mortality increased for SBP <100 mmHg [adjusted hazard ratio (aHR) 1.17, 95% confidence interval (CI) 1.11–1.24] and SBP ≥160 mmHg (aHR 1.08, 95% CI 1.04–1.13). Mortality increased linearly with higher DBP (P for trend.001), with DBP ≥90 mmHg associated with higher risk (aHR 1.10, 95% CI 1.05–1.16 for DBP ≥100 mmHg) relative to DBP 70–79 mmHg. These associations were maintained in dementia subtypes and after stratification, with a greater strength observed for older people and antihypertensive drugs use. Conclusions Individuals with dementia were revealed to have a reverse J-shaped association between SBP and all-cause mortality. The risk significantly increased with higher DBP, starting from ≥90 mmHg. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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