Acute Alcohol Consumption Reduces Uncertainty Choices.
Background and Aims: Drinking alcohol results in clear effects on decision-making in humans. Alcohol intake impairs information processing and executive function. However, the potential effects of alcohol on human uncertainty decision-making remain unknown. Design: Here we examined the pattern of un...
| Published in: | Journal of Addiction Medicine Vol. 19; no. 5; pp. 570 - 578 |
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| Main Authors: | , , , , , , |
| Format: | research tables/charts randomized controlled trial Journal Article |
| Published: |
Lippincott Williams & Wilkins
Sep/Oct2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188430765&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188430765 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19320620 3BL0 jtl: Journal of Addiction Medicine issn: 19320620 maglogo: N pubinfo: dt: Sep/Oct2025 vid: 19 iid: 5 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 188430765 188430765 188430765 10.1097/ADM.0000000000001456 188430765 ppf: 570 ppct: 8 formats: tig: atl: Acute Alcohol Consumption Reduces Uncertainty Choices. aug: au: Liu, Hao Zhang, Yi Li, Duo Wang, Chun Yuan, Ti-Fei Jia, Yanbing Wang, Fei affil: School of Rehabilitation Medicine, Shandong Second Medical University, Weifang, China (HL, YJ) sug: subj: Alcohol Drinking Uncertainty Decision Making Memory, Short Term Ethanol Pharmacodynamics Human Male Female Adult Random Assignment Comparative Studies Randomized Controlled Trials Crossover Design Analysis of Variance Breath Tests Asians Self-Rating Anxiety Scale Self-Rating Depression Scale Questionnaires Psychological Tests Scales Data Analysis Software Two-Way Analysis of Variance Linear Regression Funding Source Adult: 19-44 years Male Female ab: Background and Aims: Drinking alcohol results in clear effects on decision-making in humans. Alcohol intake impairs information processing and executive function. However, the potential effects of alcohol on human uncertainty decision-making remain unknown. Design: Here we examined the pattern of uncertain decision-making and working memory upon 3 alcohol intake paradigms (a dose of 1.5 g/L of body water, 1.0 g/L body water, and placebo beverage), with a 1-month wash-out between the 3 measurements. Twenty participants (15 males, 5 females) were randomly assigned to different groups and received alcohol drinking programs in different orders. The breath alcohol concentration was assessed to quantify alcohol intake effects, and the cortical silent period using the transcranial magnetic stimulation technique was assessed as an index for cortical inhibition level. The choice under risk and ambiguity task and N-Back task were assessed. Results: The results showed that after intake of the alcoholic beverage with a concentration is 1.5 g/L, participants reduced tolerance for risk and ambiguity, resulting in an altered pattern of uncertain decision-making. What is more, under the same condition, acute alcohol consumption (1.5 g/L) efficiently reduced accuracy and d-prime of 2- and 3-back tasks, indicating the impairment of executive function. Such changes correlate to prolonged cortical silent period. However, no significant differences were observed in the acute alcohol consumption at a concentration of 1.0 g/L. Conclusions: The study shows that alcohol intake reduces uncertain choices, along with enhanced cortical GABABR functions, suggesting alcohol-induced changes in decision-making. These findings provide insights into alcohol's mechanisms and potential targets for intervention, like transcranial magnetic stimulation on the frontal cortex or GABABR antagonist. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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