Noninvasive diagnosis and classification of kidney transplantation rejection by 18F-FAPI-04 PET/CT.
Purpose: Rejection, especially chronic rejection is a key factor influencing the prognosis of kidney transplantation patients. While 18F-fibroblast activation protein inhibitor (FAPI)-04 PET/CT has been widely utilized for diagnosing various diseases, its diagnostic efficacy in kidney transplant rej...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 52; no. 12; pp. 4685 - 4696 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188453096&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188453096 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Oct2025 vid: 52 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 188453096 185018143 10.1007/s00259-025-07307-x 188453096 ppf: 4685 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Noninvasive diagnosis and classification of kidney transplantation rejection by 18F-FAPI-04 PET/CT. aug: au: Luo, Sulin Xu, Mimi Shen, Rongfang Wang, Meifang Wu, Qinyun Zhang, Tianlu Jin, Zhenpeng Yan, Pengpeng Guo, Luying Zhou, Jingyi Zhou, Qin Wang, Huiping Zhao, Kui Su, Xinhui Wang, Rending affil: https://ror.org/05m1p5x56 Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China sug: ab: Purpose: Rejection, especially chronic rejection is a key factor influencing the prognosis of kidney transplantation patients. While 18F-fibroblast activation protein inhibitor (FAPI)-04 PET/CT has been widely utilized for diagnosing various diseases, its diagnostic efficacy in kidney transplant rejection remains unexplored. Methods: In this study, 24 kidney transplant recipients were prospectively enrolled and divided into a control cohort and a rejection cohort (KTR), which were further classified into acute rejection (AR), mixed rejection (MR), and chronic rejection (CR) subgroups. All patients underwent 18F-FAPI-04 PET/CT and 18F-FDG PET/CT scans, along with immunohistochemical FAP staining and Banff pathological scoring. The maximum and average standardized uptake values (SUVs) of the two imaging methods were calculated. Results: Compared with the control cohort, the KTR cohort showed significantly higher serum creatinine levels, lower estimated glomerular filtration rates, and lower hemoglobin levels. The SUVmax of 18F-FAPI-04 PET/CT in the allograft kidney cortex (AKC) and allograft kidney biopsy site (AKB) in the KTR cohort was significantly greater than that in the control cohort. The SUVmax of 18F-FDG PET/CT between the two cohorts was significantly different only in the AKC. For the KTR cohort, the SUVmax of 18F-FAPI-04 PET/CT in AKC and AKB was considerably greater than that of 18F-FDG PET/CT (5.5 vs. 2.8 and 3.6 vs. 2.5, respectively; both p < 0.01). In the CR cohort, the SUVmax of 18F-FAPI-04 PET/CT in the AKC, AKB, and allograft kidney medulla (AKM) was significantly greater (7.1, 5.3, and 3.2) than that of 18F-FDG PET/CT (2.5, 2.1 and 1.8) (p = 0.009, 0.009 and 0.016, respectively). The SUVmax of 18F-FAPI-04 PET/CT in AKB increased gradually in the AR, MR, and CR cohorts (2.8 vs. 3.6 vs. 5.3, p = 0.02). The above results were consistent with the SUVavg statistics. The number of FAP-positive stromal cells was different between the control and KTR groups and among the AR, MR, and CR subgroups. Conclusion: 18F-FAPI-04 PET/CT outperforms 18F-FDG PET/CT in distinguishing kidney transplant rejection, especially chronic rejection. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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