Prevalence of suboccipital and intradural vertebral artery variants: a systematic review with meta-analysis.

Purpose: The current systematic review, along with a meta-analysis, aims to present and calculate the pooled prevalence of the morphological variants of the vertebral artery (VA) within the suboccipital (V3) and intradural (V4) segments. Methods: According to the most recent guidelines, the systemat...

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Publicado en:Neuroradiology Vol. 67; no. 8; pp. 1985 - 1996
Autores principales: Triantafyllou, George, Papadopoulos-Manoralarakis, Panagiotis, Tudose, Rǎzvan Costin, Rusu, Mugurel Constantin, Tsakotos, George, Piagkou, Maria
Formato: diagnostic images meta analysis research systematic review tables/charts Journal Article
Publicado: Springer Nature Aug2025
Acceso en línea:Ver este registro en EBSCOhost
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        10.1007/s00234-025-03674-2
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      ppf: 1985
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        atl: Prevalence of suboccipital and intradural vertebral artery variants: a systematic review with meta-analysis.
      aug:
        au:
          Triantafyllou, George
          Papadopoulos-Manoralarakis, Panagiotis
          Tudose, Rǎzvan Costin
          Rusu, Mugurel Constantin
          Tsakotos, George
          Piagkou, Maria
        affil: https://ror.org/04gnjpq42 Department of Anatomy, School of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece
      sug:
        subj:
          Vertebral Artery Anatomy and Histology
          Vertebral Artery Abnormalities
          Cerebrovascular Circulation
          Neuroradiography
          Human
          Systematic Review
          Meta Analysis
          PubMed
          Magnetic Resonance Angiography
          Computed Tomography Angiography
          Confidence Intervals
          Vascular Malformations
      ab: Purpose: The current systematic review, along with a meta-analysis, aims to present and calculate the pooled prevalence of the morphological variants of the vertebral artery (VA) within the suboccipital (V3) and intradural (V4) segments. Methods: According to the most recent guidelines, the systematic review was conducted using four online databases. Eligible studies were extracted, and a meta-analysis was performed utilizing R programming software. A subgroup analysis was conducted based on nationality and imaging techniques. Results: The systematic review revealed thirty-two (32) studies involving 176,391 patients. The pooled prevalence of VA fenestration was established at 0.30% (95% CI: 0.14–0.51). Furthermore, the persistent first intersegmental artery (PFIA) was estimated to have a pooled prevalence of 1.17% (95% CI: 0.36–2.34), wherein the imaging technique and nationality served as a significant moderator. An aberrant origin of the posterior inferior cerebellar artery from the V3 segment was identified, with a pooled prevalence of 2.69% (95% CI: 1.13–4.82). Additionally, the pooled VA dominance, hypoplasia, and atresia prevalences were recorded at 27.45%, 13.41%, and 5.39%, respectively. Conclusions: Magnetic resonance or computed tomography angiographies can accurately illustrate the distal VA's diverse anatomical configurations. Specific variants hold substantial clinical significance, as they are correlated with posterior circulation cerebrovascular incidents and may complicate posterior approaches to the craniocervical region.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        meta analysis
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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