Prefrontal-hippocampal pathways underlying adolescent resilience.
The prefrontal-hippocampal pathways are integral to memory suppression, facilitating positive and adaptative responses following traumatic events. However, the role of these circuits in promoting resilience among adolescents remains largely unknown. This study used structural similarity analysis of...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 9; pp. 2815 - 2824 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188516207&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188516207 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Sep2025 vid: 34 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 188516207 184070455 188516207 188516207 10.1007/s00787-025-02704-x 188516207 ppf: 2815 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Prefrontal-hippocampal pathways underlying adolescent resilience. aug: au: Wei, Luqing Wu, Zhengdong Xia, Qi Baeken, Chris Wu, Guo-Rong affil: https://ror.org/01kj4z117 Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing, China sug: subj: Prefrontal Cortex Hippocampus Anatomy and Histology Hardiness Evaluation Adolescent Behavior Brain Mapping Gray Matter Radiography Gray Matter Anatomy and Histology Magnetic Resonance Imaging Neural Pathways Prefrontal Cortex Physiology Human Funding Source Male Female Child Adolescence Receptors, Cholinergic Neurotransmitters Spatial Perception Descriptive Statistics Data Analysis Software Chi Square Test T-Tests Pearson's Correlation Coefficient Two-Tailed Test Functional Connectivity Molecular Biology Adaptation, Physiological Memory Questionnaires Scales Serotonin Neuron Agents Child: 6-12 years Adolescent: 13-18 years Male Female ab: The prefrontal-hippocampal pathways are integral to memory suppression, facilitating positive and adaptative responses following traumatic events. However, the role of these circuits in promoting resilience among adolescents remains largely unknown. This study used structural similarity analysis of MRI-based gray matter volume (GMV) to map connectivity networks centered on the hippocampus, investigating whether structural similarity between prefrontal regions and hippocampus were related to resilience in a cohort of 145 adolescents. Additionally, spatial correlation analyses of resilience-related structural similarity network and neurotransmitter distribution maps were conducted to identify molecular adaptations within prefrontal-hippocampal circuits associated with resilience. The results showed that higher resilience levels were correlated with stronger structural similarity between the prefrontal areas (i.e., middle frontal gyrus and orbitofrontal cortex) and hippocampus. Furthermore, the serotonergic neurotransmitter system, which modulates neural oscillations in prefrontal-hippocampal pathways, appears to be associated with resilience. The current findings suggest that structural and molecular adaptations within prefrontal-hippocampal circuits, which are implicated in the suppression of intrusive, unwanted memories, may foster resilience in young people. These insights advance our knowledge of the neurobiological markers of resilience, paving the way for more targeted and effective therapeutic interventions to bolster resilience and mitigate adverse outcomes in developmental populations. pubtype: Academic Journal doctype: diagnostic images equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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